Spijkers is a Dutch surname. Notable people with the surname include:
- Ben Spijkers (born 1961), Dutch judoka
- Cas Spijkers (1946–2011), Dutch chef and writer
- Jur Spijkers (born 1997), Dutch judoka
See also
- Spijkers v Gebroeders Benedik Abattoir CV, United Kingdom labour law case
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