Spike is a nickname of the following people:

Arts and entertainment

• Spike Feresten (born 1964), American television writer and talk show host
• Spike Jones (1911–1965), American musician and bandleader
• Spike Jonze (born 1969), American filmmaker and photographer
• Spike Lee (born 1957), American filmmaker
• Spike Milligan (1918–2002), Irish satirist, creator of The Goon Show
• Spike Robinson (1930–2001), jazz musician
• Spike Spencer (born 1968), American voice actor
• Spike Stent (born 1965), English record producer and mixing engineer
• Spike Trotman, American cartoonist and publisher
• Spike Wells (born 1946), English jazz drummer and priest

Sports

• Spike Albrecht (born 1992), American college basketball player
• Spike Gehlhausen (born 1954), American race car driver
• Spike Jones (American football) (born 1947), American former National Football League punter
• Spike McRoy (born 1968), American golfer
• Spike Pola (1914–2012), Australian rules footballer

Military

• William H. P. Blandy (1890–1954), US Navy admiral
• William Eckert (1909–1971), US Air Force lieutenant general and fourth Commissioner of Major League Baseball
• William W. Momyer (1916–2012), US Air Force general and World War II flying ace

Politics

• Spike Cohen (born 1982), American libertarian vice presidential candidate, political activist, entrepreneur, and podcaster

Fictional characters

• Spike (Peanuts), Snoopy's brother in the Peanuts comic strip
• Spike the Bulldog (disambiguation)
• Spike the Dragon, a character from My Little Pony: Friendship is Magic
• Spike Spiegel, a character from Cowboy Bebop
• Spike Pratt, a character from Buffy the Vampire Slayer and Angel
• Spike, multiple characters from Marvel Comics