Túpac Amaru (1545–1572) was the last indigenous leader of the Inca empire.
Túpac Amaru may also refer to:
- Túpac Amaru II (1742–1781), Peruvian leader of an indigenous uprising
- Túpac Amaru Revolutionary Movement, a Peruvian communist guerrilla group
- Tupac Amaru Hunter (born 1973), Michigan politician
- Tupac Amaru Shakur (1971–1996), American rapper
See also
- Tupamaros, a Uruguayan communist guerrilla group
- Tupamaro (Venezuela), a political party of Venezuela until 2007
- Tupac (name), a given name (and list of people with that name)
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