Takaishi may refer to:
- Takaishi, Osaka, a city in Osaka Prefecture, Japan
- Takaishi, a character in Kodomo no Omocha
- Takeru "T.K." Takaishi, a character in Digimon
People with the surname
- Katsuo Takaishi (高石 勝男, 1906–1966), Japanese swimmer
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