Atenolol/chlorthalidone
Combination of
AtenololBeta blocker
ChlorthalidoneDiuretic
Clinical data
Trade namesTenoretic, Tenoret, others
AHFS/Drugs.comFDA Professional Drug Information
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
KEGG

Atenolol/chlorthalidone, also known as co-tenidone, is a combination medication used to treat high blood pressure.[2][3] It is made up of atenolol, a beta-blocker and chlortalidone, a diuretic.[4] It is not recommended as an initial treatment but may be used in those who are taking atenolol and chlortalidone individually.[5] It is taken by mouth.[2]

Common side effects include gastrointestinal upset and gout.[3] Serious side effects may include liver problems, pancreatitis, and psychosis.[3] Use is not recommended during pregnancy.[3] Use during breastfeeding may harm the baby.[2] Atenolol works by blocking β1-adrenergic receptors in the heart, thus decreasing the heart rate and workload.[3] Chlorthalidone works by increasing the amount of sodium lost by the kidneys.[2]

The combination was approved for medical use in the United States in 1984.[4] It is available as a generic medication.[3] In 2017, it was the 304th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[6]

References

  1. ↑ "Tenoret 50 mg/12.5 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 29 November 2019. Retrieved 4 May 2020.
  2. 1 2 3 4 "DailyMed - atenolol and chlorthalidone tablet". dailymed.nlm.nih.gov. Retrieved 18 April 2019.
  3. 1 2 3 4 5 6 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 153. ISBN 9780857113382.
  4. 1 2 "Atenolol and Chlorthalidone Tablets - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
  5. ↑ "Atenolol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 April 2019.
  6. ↑ "Atenolol; Chlorthalidone - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.


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