The Lyre of Orpheus may refer to:

• The lyre belonging to the legendary Greek figure Orpheus
• The Lyre of Orpheus (novel), a novel by Robertson Davies
• Abattoir Blues / The Lyre of Orpheus, an album by Nick Cave and the Bad Seeds, or the song "The Lyre of Orpheus"

See also

• Lyra, a constellation associated, in Greek mythology, with the lyre of Orpheus