Trapani is a surname. Notable people with the surname include:
- Enzo Trapani (1922–1989), Italian screenwriter, set designer, television producer/director and film director
- Francesco Trapani (born 1957), Italian chief executive
- Gina Trapani (born 1975), American tech blogger, web developer and writer
- Joe Trapani (born 1988), American basketball player
- Sal Trapani (1927–1999), American comic-book artist
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