Oxycodone/paracetamol
Combination of
OxycodoneOpioid analgesic
ParacetamolAnilide analgesic
Clinical data
Trade namesPercocet, others
AHFS/Drugs.comProfessional Drug Facts
License data
Routes of
administration		By mouth
ATC code
Legal status
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CAS Number
ChemSpider
KEGG
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Oxycodone/paracetamol, sold under the brand name Percocet among others, is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.[1]

In 2020, it was the 69th most commonly prescribed medication in the United States, with more than 10 million prescriptions.[2][3]

History

The United States Food and Drug Administration (FDA) first approved Percocet in 1976, under application ANDA 085106.[4]

Society and culture

Implicated in deaths

In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[5] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.[6]

In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.[7][8][9]

In March 2017, U.S. President Donald Trump initiated the Opioid and Drug Abuse Commission.[10] In July 2017, a draft report was published.[11]

References

  1. 1 2 "Percocet- oxycodone hydrochloride and acetaminophen tablet". DailyMed. Retrieved 17 October 2021.
  2. ↑ "The Top 300 of 2019". ClinCalc. Retrieved 7 October 2022.
  3. ↑ "Acetaminophen; Oxycodone - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
  4. ↑ "Percocet: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 17 October 2021.
  5. ↑ "FDA May Restrict Acetaminophen". WebMD.
  6. ↑ Harris G (30 June 2009). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times. Retrieved 22 May 2010.{{cite news}}: CS1 maint: overridden setting (link)
  7. ↑ Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN (December 2009). "Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone". CMAJ. 181 (12): 891–6. doi:10.1503/cmaj.090784. PMC 2789126. PMID 19969578.
  8. ↑ Fischer B, Rehm J (December 2009). "Deaths related to the use of prescription opioids". CMAJ. 181 (12): 881–2. doi:10.1503/cmaj.091791. PMC 2789122. PMID 19969577.
  9. ↑ "Deaths from opioid use have doubled; five-fold increase in oxycodone deaths". Canadian Medical Association Journal. 7 December 2009. Retrieved 31 May 2012.
  10. ↑ "Presidential Executive Order Establishing the President's Commission on Combating Drug Addiction and the Opioid Crisis". 29 March 2017. Archived from the original on 30 March 2017.
  11. ↑ "Draft interim report" (PDF). whitehouse.gov – via National Archives.
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