Early life

Mary Mallon was born in 1869 in Cookstown, County Tyrone, Ireland. She may have been born with typhoid fever as her mother was infected during pregnancy.^[5][6][7] In 1884 at the age of 15, she emigrated from Ireland to the United States.^[6][8] She lived with her aunt and uncle for a time and worked as a maid, but eventually became a cook for affluent families.^[9][10]

Career

From 1900 to 1907, Mallon worked as a cook in the New York City area for eight families, seven of whom contracted typhoid.^[11][12] In 1900, she worked in Mamaroneck, New York, where within two weeks of her employment, residents developed typhoid fever. In 1901, she relocated to Manhattan, where members of the family for whom she worked developed fevers and diarrhea. Mallon then went to work for a lawyer and left after seven of the eight people in that household became ill.^[13][14]

In June 1904, she was hired by a prosperous lawyer, Henry Gilsey. Soon four of the seven servants were ill. No members of Gilsey's family were infected because they resided separately, and the servants lived in their own house. Immediately after the outbreak began, Mallon left and relocated to Tuxedo Park,^[15] where she was hired by George Kessler. Two weeks later, the laundry worker in his household was infected and taken to St. Joseph's Regional Medical Center, where her case of typhoid was the first in a long time. The investigator Dr. R. L. Wilson concluded that the laundry worker had caused the outbreak, but he failed to prove it. The laundry worker died soon afterward.^[10]

In August 1906, Mallon began a job in Oyster Bay on Long Island with the family of a wealthy New York banker, Charles Elliot Warren.^[16] Mallon went along with the Warrens when they rented a house in Oyster Bay for the summer of 1906. From August 27 to September 3, six of the 11 people in the family came down with typhoid fever. The disease at that time was "unusual" in Oyster Bay, according to three medical doctors who practiced there. The landlord, understanding that it would be difficult to rent a house with the reputation of having typhoid, hired several independent experts to find the source of infection. They took water samples from pipes, faucets, toilets, and the cesspool, all of which were negative for typhoid.^{[1][17][18] [13]}

Investigation

George Soper, an investigator hired by the Oyster Bay property owner after the outbreak there, had been trying to determine the cause of typhoid outbreaks in affluent families, when it was known that the disease typically occurred in unsanitary conditions. He discovered that a female Irish cook, who fit the physical description he had been given, was involved in all of the outbreaks. He was unable to locate her because she generally left after an outbreak began, without giving a forwarding address. The Park Avenue outbreak helped to identify Mallon as the source of the infections. Soper learned of the case while it was still active and discovered Mallon was the cook.^[13]

Soper first met Mallon in the kitchen of the Bownes' Park Avenue penthouse and accused her of spreading the disease. Though Soper himself recollected his behavior "as diplomatic as possible," he infuriated Mallon and she threatened him with a carving fork.^[13][19] When Mallon refused to give samples, Soper decided to compile a five-year history of her employment. He found that, of the eight families that had hired Mallon as a cook, members of seven claimed to have contracted typhoid fever.^[20] Then Soper learned where Mallon's boyfriend lived and arranged a new meeting there. He took Dr. Raymond Hoobler in an attempt to persuade Mary to give them samples of urine and stool for analysis. Mallon again refused to cooperate, claiming that typhoid was everywhere and that the outbreaks had happened because of contaminated food and water. At that time, the concept of healthy carriers was unknown even to healthcare workers.^[10][21][22]

Soper published his findings on June 15, 1907, in the Journal of the American Medical Association.^[23] He wrote:

It was found that the family changed cooks on August 4. This was about three weeks before the typhoid epidemic broke out. The new cook, Mallon, remained in the family only a short time and left about three weeks after the outbreak occurred. Mallon was described as an Irish woman about 40 years of age, tall, heavy, single. She seemed to be in perfect health.^[24]

First quarantine (1907–1910)

Mallon (foreground) in a hospital bed.

Soper notified the New York City Health Department, whose investigators realized that Mallon was a typhoid carrier. By sections 1169 and 1170 of the Greater New York Charter, Mallon was arrested as a public health threat. She was forced into an ambulance by five policemen and Dr. Josephine Baker, who at some time had to sit on Mallon to restrain her.^[21] Mallon was transported to the Willard Parker Hospital, where she was restrained and forced to give samples. For four days, she was not allowed to get up and use the bathroom on her own.^[25] The massive numbers of typhoid bacteria that were discovered in her stool samples indicated that the infection source was in her gallbladder. During questioning, Mallon admitted that she almost never washed her hands. This was not unusual at the time; the germ theory of disease still was not fully accepted.^[13][26]

On March 19, 1907, Mallon was sentenced to quarantine on North Brother Island. While quarantined she gave stool and urine samples three times per week. Authorities suggested removing her gallbladder, but she refused because she claimed she did not believe she carried the disease. At the time, gallbladder removal was dangerous, and people had died from the procedure.^[27] Mallon was also unwilling to stop working as a cook, a job that earned more money for her than any other. Having no home of her own, she was always on the verge of poverty.

After the publication of Soper's article in the Journal of the American Medical Association, Mallon attracted extensive media attention and received the nickname "Typhoid Mary."^[28] Later, in a textbook that defined typhoid fever, she again was termed "Typhoid Mary."^[29]

Soper visited Mallon in quarantine, telling her he would write a book and give her part of the royalties.^[30] She angrily rejected his proposal and locked herself in the bathroom until he left.^[31] She hated the nickname and wrote in a letter to her lawyer:

I wonder how the said Dr. William H. Park would like to be insulted and put in the Journal and call him or his wife Typhoid William Park.^[28]

Not all medical experts endorsed the decision to forcibly quarantine Mallon. For example, Milton J. Rosenau and Charles V. Chapin both argued that she just had to be taught to carefully treat her condition and ensure that she would not transmit the typhoid to others. Both considered isolation to be an unnecessary, overly strict punishment.^[32] Mallon suffered from a nervous breakdown after her arrest and forcible transportation to the hospital. In 1909 she tried to sue the New York Health Department, but her complaint was denied and the case dismissed by the New York Supreme Court.^[33] In a letter to her lawyer she complained that she was treated like a "guinea pig." She was obliged to give samples for analysis three times a week, but for six months was not allowed to visit an eye doctor, even though her eyelid was paralyzed and she had to bandage it at night. Her medical treatment was hectic: she was given urotropin in three-month courses for a year, threatening to destroy her kidneys. That was changed to brewer's yeast and hexamethylenetetramine in increasing doses.^[34][28][35] She was first told that she had typhoid in her intestinal tract, then in her bowel muscles, then in her gallbladder.^[28]

Mallon herself claimed never to believe that she was a carrier. With the help of a friend, she sent several samples to an independent New York laboratory. All came back negative for typhoid.^[32] On North Brother Island, almost a quarter of her analyses from March 1907 through June 1909 were also negative.^[25] After 2 years and 11 months of Mallon's quarantine, Eugene H. Porter, the New York State Commissioner of Health, decided that disease carriers should no longer be quarantined and that Mallon could be freed if she agreed to stop working as a cook and take reasonable efforts to avoid transmitting typhoid to others. On February 19, 1910, Mallon said she was "prepared to change her occupation (that of a cook), and would give assurance by affidavit that she would upon her release take such hygienic precautions as would protect those with whom she came in contact, from infection."^[36] She was released from quarantine and returned to the mainland.^[35][37][38]

Release and second quarantine (1915–1938)

Poster depiction of "Typhoid Mary" (1909).

Upon her release, Mallon was given a job as a laundry worker, which paid less than cooking—$20 per month instead of $50. After a time she wounded her arm and the wound became infected, meaning that she could not work at all for six months.^[39] After several unsuccessful years, she started cooking again. She used fake surnames like Breshof or Brown, and accepted jobs as a cook against the explicit instructions of health authorities. No agencies that hired servants for affluent families would offer her employment, so for the next five years, she worked in a number of kitchens in restaurants, hotels, and spa facilities. Almost everywhere she worked, there were outbreaks of typhoid.^[36] However, she changed jobs frequently, and Soper was unable to find her.^[13]

In 1915, Mallon started working at Sloane Hospital for Women in New York City. Soon 25 people were infected, and two died. The chief obstetrician, Dr. Edward B. Cragin, called Soper and asked him to help in the investigation. Soper identified Mallon from the servants' verbal descriptions and also by her handwriting.^[36][39]

Mallon fled again, but the police were able to find and arrest her when she took food to a friend on Long Island.^[13][37] Mallon was returned to quarantine on North Brother Island on March 27, 1915.^[37][39]

Little is known about her life during the second quarantine. She remained on North Brother for more than 23 years, and the authorities gave her a private one-story cottage. As of 1918, she was allowed to take day trips to the mainland. In 1925, Dr. Alexandra Plavska came to the island for an internship. She organized a laboratory on the second floor of the chapel and offered Mallon a job as a technician. Mallon washed bottles, did recordings, and prepared glasses for pathologists.^[40][41]

Media reception

After Mallon was sent into her initial quarantine, the newspapers changed their opinion of her case. The articles at first mentioned how Dr. Josephine Baker claimed Mallon attacked her and the other doctors with forks, and came at them fighting and swearing.^[42] Later the press articles shifted the blame away from being her fault, the claim being that she was unaware she was carrying anything and instead germs that she had no control over were to blame.^[42] The newspapers also claimed that Mallon was prohibited from using the telephone to contact anybody except the surgeons treating her and her guard. Stories that once celebrated the public health department and legal system eventually became sympathetic to Mallon and the events she supposedly encountered.^[42] Public health officials claimed the opposite, that she was treated to their best ability but in return refused to comply with the requests of the health officials.^[43] 

Aftermath

Mallon's case became the first in which an asymptomatic carrier was discovered and isolated forcibly. The ethical and legal issues raised by her case are still discussed.^[6][50][51] Research has resulted in an estimate that Mallon had contaminated "at least one hundred and twenty two people, including five dead".^[1] Other sources attribute at least three deaths to contact with Mallon, but because of health officials' inability to persuade her to cooperate, the exact number is not known. Some have estimated that contact with her may have caused 50 fatalities.^[13]

In a 2013 article in the Annals of Gastroenterology, the authors concluded:

The history of Mary Mallon, declared "unclean" like a leper, may give us some moral lessons on how to protect the ill and how we can be protected from illness [...] By the time she died New York health officials had identified more than 400 other healthy carriers of Salmonella typhi, but no one else was forcibly confined or victimized as an "unwanted ill".^[1]

Two scholarly sources combined to provide this conclusion:

This case highlighted the problematic nature of the subject and the need for an enhanced medical and legal-social treatment model aimed at improving the status of disease carriers and limiting their impact on society.^[52]

Other healthy typhoid carriers identified in the first quarter of the 20th century include Tony Labella, an Italian immigrant, presumed to have caused more than 100 cases (with five deaths); an Adirondack guide dubbed "Typhoid John", presumed to have infected 36 people (with two deaths); and Alphonse Cotils, a restaurateur and bakery owner.^[53]

The health technology of the era did not have a completely effective solution: there were not any antibiotics to fight the infection, and gallbladder removal was a dangerous, sometimes fatal operation. Some modern specialists claim that typhoid bacteria can become integrated in macrophages and then reside in intestinal lymph nodes or the spleen.^[54][55]

Ethics

The ethical question of her arrest and forced quarantine is still being debated. Historians frequently discuss the argument of Mallon knowing that she was infecting her clients with typhoid based on the frequency of the disease being present after her departure. They also cite the argument that antibiotics did not exist at this time and ten percent of those affected by Mallon carrying the infection died.^[56] By this argument Mallon could be considered a murderer of those ten percent of people if she knew she was a carrier of the disease, and would be a justification for her arrest.

Others argue that Mallon did not know that she had the bacteria and therefore did not deserve to be arrested when she never committed a crime. At the time, asymptomatic carriers were not understood and Mallon was believed to have said that she did not feel sick, look sick, or have any sort of visible sickness. Although Mallon did not feel ill or look sick, the disease was living dormant in what was assumed to be her gallbladder.^[57]

Lessons learned

A historical poster warning against acting like Typhoid Mary.

Mallon was the first person found to be an asymptomatic carrier of the typhoid bacterium, and this caused the health officials to have little to no idea of how to deal with her. However, Mallon's case helped these officials identify other people who carried diseases that were dormant in their bodies based on the information they learned from Mallon's case. Mallon's case created controversy concerning personal autonomy and social responsibility. It also was the first case that provided good evidence of the existence of asymptomatic carriers.^[43]

In culture

The phrase "Typhoid Mary" is now a colloquial term for anyone who, knowingly or not, spreads disease or something else undesirable.^[58]

Typhoid Mary Fisk, also known as Bloody Mary and Mutant Zero, is a fictional supervillain appearing in American comic books published by Marvel Comics.^[59]

Mallon's case inspired the name of the rap music group Hail Mary Mallon.^[60]

Mallon was portrayed by Melissa McMeekin in season one of the television series The Knick,^[61] in a somewhat fictionalised account of her initial infection of countless wealthy households.

Mallon's butcher knife featured as an artifact in season three of the television series Warehouse 13.^[62] Associated with Mallon's legacy with disease, the fictional artifact had the ability to transfer illness between individuals holding the knife simultaneously.