Mexico to Los Angeles

The highway started at the border with Baja California in Calexico, California. It then continued north along the western shore of the Salton Sea. The stretch is now known as SR 86. US 99 continued along present-day SR 111 through Coachella to its intersection at Dillon Road with another major US route signed as both US 60 and US 70.

Now signed as US 60/US 70/US 99, the highway continued north through Indio and turned west through the San Gorgonio Pass toward Los Angeles paralleling the route of modern I-10. In Beaumont, US 60 split off on its own westward trek to Los Angeles. The highway through Banning and Beaumont (known as Ramsey Street in Banning and Sixth Street in Beaumont) was bypassed by the new superhighway version of US 60/US 70/US 99 that would later become part of I-10. The edges of the old US 60 shield at the replacement interchange's overhead sign are clearly visible today underneath the SR 60 shield that covers it. Prior to the construction of the superhighway, US 99 entered Los Angeles on Valley Boulevard, multiplexed with US 70.

US 70 ended in downtown LA while US 99 turned north once again more or less following the route of today's I-5 (San Fernando Road in the San Fernando Valley before the construction of I-5), up and over the Tehachapi Mountains to the San Joaquin Valley. US 99's original alignment over the rugged Tehachapi Mountains was known in its earliest days as the Ridge Route, the first highway directly linking the Los Angeles Basin to the San Joaquin Valley. Built in 1915, the alignment between Castaic and SR 138 to Gorman is listed on the National Register of Historic Places. The original Ridge Route at the south and the Grapevine at the north was an exceptionally twisty and narrow two-lane concrete road that was very slow to travel along the ridge precipices and was considered dangerous to drive in the days of the Model A Ford and overheating trucks. It was bypassed in 1933 by the three-lane "Alternate Ridge Route", some of which now sits at the bottom of Pyramid Lake. Dropping down from the Tehachapis, US 99 entered the San Joaquin Valley at the bottom of the steep Grapevine grade (the foot of the Tejon Pass) and continued north.

Los Angeles

When it was first designated in late 1926, US 99 ran with US 66 from San Bernardino via Pasadena to Los Angeles, turning north there to San Fernando.^[4] The route was signed in 1928. This alignment remained through 1933, but by 1942 it had moved to its own alignment (concurrent with US 70, as well as US 60 west of Pomona) from San Bernardino to Los Angeles. This alignment used Garvey Avenue from Pomona, turning onto Ramona Boulevard in Alhambra to reach Macy Street (now Cesar E. Chavez Avenue) near downtown Los Angeles. It turned north at Figueroa Street, running through the Figueroa Street Tunnels and turning off at Avenue 26 to reach San Fernando Road. When the San Bernardino Freeway, Santa Ana Freeway and Pasadena Freeway were completed, it was routed onto them, continuing to exit at Avenue 26.^[5] In 1962, with the completion of the Golden State Freeway northeast of downtown, US 99 was moved onto it, bypassing the Santa Ana Freeway, Four Level Interchange and Figueroa Street Tunnels.

Los Angeles to Sacramento

A section of the 1915 Ridge Route in Lebec, abandoned when US 99 (Ridge Route Alternate) opened over Tejon Pass in 1933

From Los Angeles US 99 followed San Fernando Road through Glendale and Burbank to Sylmar. From 1937 to 1964 it shared this routing with US 6; the remaining stretch of the highway through the Santa Clarita Valley is named "The Old Road". The Old Road starts near the Newhall Pass Interchange, just south of Santa Clarita, eventually crossing under present-day I-5. As the road now winds north, passing by Pico Canyon Road, it reaches McBean Parkway near the California Institute of the Arts, College of the Canyons and Six Flags Magic Mountain. In Castaic the Old Road becomes a suburban street and ends at Oak Hill Court, just outside Castaic. A substantial portion of the road is submerged beneath Pyramid Lake; the northern side is now the lake's public access road, while the southern side is access to the dam.^[6]

US 99 then headed over Tejon Pass to the San Joaquin Valley. Just north of the route's entry to the valley, I-5 splits off from US 99, and US 99 continued on the current route of SR 99, to Bakersfield, Fresno, and Sacramento. Many older segments of the highway between the "Grapevine" and Sacramento still exist as local streets, many of them having "Golden State" in their names (such as Golden State Avenue, Golden State Boulevard, Golden State Highway).

Sacramento to Oregon

North of Sacramento, the route divided into US 99W and US 99E. US 99W co-routed with US 40 west to Davis, in city as Olive Drive. The route continued as Richards Boulevard, 1st Street, B Street, and Russell Boulevard before turning north on what is now SR 113 into Woodland to meet and parallel I-5 near the town of Yolo. From there, the route parallels the current I-5, entering Corning from the South as Old Corning road, turning east onto Solano Street before turning north again on 3rd street continuing to Red Bluff, where it became Main Street. All of the old inter-town original roadway still exists, signed as 99W, CR 99 or CR 99W.

From Sacramento US 99E followed I-80 (first the current business route, then the actual route) to Roseville, then north along SR 65 to Olivehurst, from where it followed SR 70 to Marysville. From Marysville it followed SR 20 across the Feather River to Yuba City, then along the current SR 99 north to Red Bluff, where it rejoined 99W at Main Street and Antelope Boulevard.

From Red Bluff US 99 continued north along the same route as I-5, except that it went through Redding along present SR 273. and SR 263 from Yreka to near Black Mountain.

Old 99 Highway in Siskiyou County

From Redding, the highway went through the small town of Mountain Gate, before plunging into what is now Shasta Lake.^[7] In drought years, many of the old bridges, road cuts, and guardrail can be seen when the water in the lake recedes. After passing Shasta Lake, the highway had to be designed around very difficult terrain. The Sacramento River Canyon was a big task to overcome, but to this day, many bridges can still be found and visited, reminding us of how far our engineering has come. Once into Siskiyou County, the highway meanders through Dunsmuir, heading north to Mount Shasta, and from there, up to Weed. In Weed, the highway becomes SR 265 for a very short distance, before heading north towards the town of Gazelle.^[8]

A 22.7-mile-long (36.5 km) stretch of two-lane county road known as "Old Highway 99" exists in Siskiyou County, between Weed and Yreka, in the same form as it did when it was US 99. It roughly parallels I-5, but at one point diverges from it by a distance of several miles. Once north of Yreka, the highway becomes SR 263, merges with SR 96, and heads north to Hornbrook. Much of the old highway between Hornbrook and Oregon has been demolished or currently sits on private property.

US 99E major intersections

County	Location	mi[9]	km	Destinations	Notes
Sacramento	Sacramento	0	0.0	US 99 south – Stockton US 40 west / US 99W north / SR 16 west – San Francisco	Southern end of US 40 overlap; northern end of SR 16 overlap
Placer	Roseville	18	29	US 40 east – Reno	Northern end of US 40 overlap
Yuba	Marysville	52	84	SR 20 east / SR 24 north	Southern end of SR 20 and SR 24 overlaps
Sutter	Yuba City	54	87	SR 20 west / SR 24 south	Northern end of SR 20 and SR 24 overlaps
Butte	Chico	101	163	SR 32 – Orland, Chester
Tehama	Red Bluff	138	222	SR 36 east – Susanville	Southern end of SR 36 overlap
		141	227	US 99 north / SR 36 west – Redding US 99W south – Sacramento	Northern end of SR 36 overlap
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

US 99W major intersections

County	Location	mi[9]	km	Destinations	Notes
Sacramento	Sacramento	0	0.0	US 99 south / SR 16 east – Stockton US 40 east / US 99E north – Reno	Southern end of US 40 overlap
				SR 16 north / SR 24 – Woodland, Isleton	Northern end of SR 16 overlap
Yolo	Davis	14	23	US 40 west – San Francisco	Northern end of US 40 overlap
	Woodland	26	42	SR 16 east / SR 24 – Sacramento, Marysville	Southern end of SR 16 overlap
		28	45	SR 16 west – Madison	Northern end of SR 16 overlap
Colusa	Williams	66	106	SR 20 – Colusa, Clear Lake
Glenn	Orland	108	174	SR 32 east – Chico
Tehama	Red Bluff	139	224	US 99 north / SR 36 west – Redding US 99E south / SR 36 east – Chico
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus