UBA52
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesUBA52, CEP52, HUBCEP52, L40, RPL40, Ubiquitin A-52 residue ribosomal protein fusion product 1
External IDsOMIM: 191321 MGI: 3644625 HomoloGene: 68307 GeneCards: UBA52
Orthologs
SpeciesHumanMouse
Entrez

7311

665964

Ensembl

ENSG00000221983

n/a

UniProt

P62987

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 19: 18.57 – 18.58 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.[4][5]

Function

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N-terminus and ribosomal protein L40 at the C-terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000221983 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Webb GC, Baker RT, Coggan M, Board PG (Jun 1994). "Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12". Genomics. 19 (3): 567–9. doi:10.1006/geno.1994.1108. PMID 8188300.
  5. 1 2 "Entrez Gene: UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1".

Further reading


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