Ubiquitin carboxyl-terminal hydrolase L5

UCHL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A7S, 3IHR, 3RII, 3RIS, 3TB3, 4UEL, 4UEM, 4UF5, 4UF6, 4WLP
Identifiers
Aliases	UCHL5, CGI-70, INO80R, UCH-L5, UCH37, Ubiquitin carboxyl-terminal hydrolase L5, ubiquitin C-terminal hydrolase L5
External IDs	OMIM: 610667 MGI: 1914848 HomoloGene: 9326 GeneCards: UCHL5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	193,060,080 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	143,683,204 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; islet of Langerhans; ; body of pancreas; ; prefrontal cortex; ; rectum; ; monocyte; ; gastrocnemius muscle; ; ganglionic eminence; ; endothelial cell; ; stromal cell of endometrium;
	Top expressed in
	morula; ; yolk sac; ; parotid gland; ; otic placode; ; medial vestibular nucleus; ; blastocyst; ; abdominal wall; ; pontine nuclei; ; saccule; ; dorsal tegmental nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; thiol-dependent deubiquitinase; peptidase activity; protein binding; endopeptidase inhibitor activity; hydrolase activity; RNA binding; proteasome binding;
Cellular component	cytoplasm; intracellular anatomical structure; proteasome complex; nucleus; cytosolic proteasome complex; nucleoplasm; mitochondrion; cytosol; Ino80 complex;
Biological process	regulation of proteasomal protein catabolic process; DNA recombination; regulation of transcription, DNA-templated; lateral ventricle development; ubiquitin-dependent protein catabolic process; transcription, DNA-templated; proteolysis; cellular response to DNA damage stimulus; forebrain morphogenesis; DNA repair; midbrain development; negative regulation of endopeptidase activity; protein deubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51377
	56207
	ENSG00000116750
	ENSMUSG00000018189
	Q9Y5K5; Q5LJB0
	Q9WUP7
NM_001199261; NM_001199262; NM_001199263; NM_015984; NM_001350840;
	NM_001350841; NM_001350842; NM_001350843; NM_001350844; NM_001350845; NM_001350846; NM_001350847; NM_001350848; NM_001350849; NM_001350850; NM_001350851; NM_001350852
	NM_001159866; NM_019562
NP_001186190; NP_001186191; NP_001186192; NP_057068; NP_001337769;
	NP_001337770; NP_001337771; NP_001337772; NP_001337773; NP_001337774; NP_001337775; NP_001337776; NP_001337777; NP_001337778; NP_001337779; NP_001337780; NP_001337781
	NP_001153338; NP_062508
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116750 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018189 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
↑ Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, Dijke PT, Chantry A (Dec 2005). "The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling". Oncogene. 24 (54): 8080–4. doi:10.1038/sj.onc.1208944. PMID 16027725.
↑ "Entrez Gene: UCHL5 ubiquitin carboxyl-terminal hydrolase L5".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37". FEBS Lett. 488 (3): 201–5. doi:10.1016/S0014-5793(00)02436-4. hdl:10536/DRO/DU:30009147. PMID 11163772. S2CID 40717095.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389. S2CID 6633207.
Gandhi TK, Zhong J, Mathivanan S, et al. (2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets". Nat. Genet. 38 (3): 285–93. doi:10.1038/ng1747. PMID 16501559. S2CID 1446423.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Yao T, Song L, Xu W, et al. (2006). "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1". Nat. Cell Biol. 8 (9): 994–1002. doi:10.1038/ncb1460. PMID 16906146. S2CID 25308728.
Hamazaki J, Iemura S, Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes". EMBO J. 25 (19): 4524–36. doi:10.1038/sj.emboj.7601338. PMC 1589993. PMID 16990800.
Qiu XB, Ouyang SY, Li CJ, et al. (2007). "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37". EMBO J. 25 (24): 5742–53. doi:10.1038/sj.emboj.7601450. PMC 1698896. PMID 17139257.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116750 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018189 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[pmid16027725-6] Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, Dijke PT, Chantry A (Dec 2005). "The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling". Oncogene. 24 (54): 8080–4. doi:10.1038/sj.onc.1208944. PMID 16027725.

[entrez-7] "Entrez Gene: UCHL5 ubiquitin carboxyl-terminal hydrolase L5".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Thioesterases (EC 3.1.2)
Acetyl-CoA thioesterases
Acyl-CoA thioesterases	ACOT1 ACOT2 ACOT4 ACOT6 ACOT7 ACOT8 ACOT9 ACOT11 ACOT12 ACOT13
Formyl-CoA thioesterases
Palmitoyl protein thioesterases	PPT1 PPT2
Succinyl-CoA thioesterases
Ubiquitin C-terminal hydrolases	UCHL1 UCHL3 UCHL5

References

Further reading