| UDP-N-acetylglucosamine 4-epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 UDP-N-acetylglucosamine 4-epimerase homodimer, Pseudomonas aeruginosa | |||||||||
| Identifiers | |||||||||
| EC no. | 5.1.3.7 | ||||||||
| CAS no. | 9024-16-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-glucosamine UDP-N-acetyl-D-galactosamine
Hence, this enzyme has one substrate, UDP-N-acetyl-D-glucosamine, and one product, UDP-N-acetyl-D-galactosamine.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine 4-epimerase. Other names in common use include UDP acetylglucosamine epimerase, uridine diphosphoacetylglucosamine epimerase, uridine diphosphate N-acetylglucosamine-4-epimerase, and uridine 5'-diphospho-N-acetylglucosamine-4-epimerase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1SB8 and 1SB9.
References
- Glaser L (November 1959). "The biosynthesis of N-acetylgalactosamine". The Journal of Biological Chemistry. 234 (11): 2801–5. doi:10.1016/S0021-9258(18)69673-5. PMID 13828347.
- Kornfeld S, Glaser L (October 1962). "The synthesis of thymidine-linked sugars. v. thymidine diphosphate-amino sugars". The Journal of Biological Chemistry. 237 (10): 3052–9. doi:10.1016/S0021-9258(18)50119-8. PMID 14034827.