USCGC Pamlico may refer to the following United States Coast Guard cutters that are named for Pamlico Sound:
- USRC Pamlico (1907), a revenue cutter in service from 1907 through 1946. From 1915 to 1946 known as USCGC Pamlico.
- USCGC Pamlico (WLIC–800), a 160–foot inland construction tender in service since 1976.
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