Solomon Islands Campaign

She landed U.S. Marines and their equipment in the initial assault on Guadalcanal 7 August, and through the next months continued to sail out of Wellington to bring reinforcements and supplies to Guadalcanal and South Pacific bases, often coming under Japanese air attack. As U.S. Army troops relieved the battle-weary marines on Guadalcanal, Fuller carried soldiers from Noumea and Suva to Guadalcanal. In May 1943 she sailed to Pearl Harbor to load marines for transportation to Australia, then returned to her transport duties from New Zealand and Australia to South Pacific bases.

On 28 October 1943, Fuller sailed from Efate, New Hebrides, for the initial landings on Bougainville, where she landed Marine raiders on Cape Torokina 1 November. Laden with casualties, she cleared the assault beaches the same day for Tulagi and Purvis Bay. Returning to Bougainville's Empress Augusta Bay anchorage with reinforcements 8 November, Fuller came under enemy air attack, receiving a direct hit on her port side which set her afire and killed five of her crew and two soldiers embarked. She returned to Purvis Bay 2 days later to repair battle damage, and twice more during the following month and a half carried reinforcements to Bougainville.

Marianas and Peleliu

After a U.S. West Coast overhaul between 18 January 1944 and 20 March, Fuller trained at San Diego, California, and in the Hawaiian Islands for the Marianas assault. She sailed from Pearl Harbor 29 May for Saipan, where on the morning of 15 June she staged in a feint landing before putting her troops ashore in the actual assault. Ordered away from the island for safety during the Battle of the Philippine Sea, Fuller completed unloading her cargo 24 June, and sailed for Eniwetok with prisoners of war on board.

For the invasion of Tinian, 24 July 1944, Fuller again staged a diversionary feint at landings, then landed her marines next day as reinforcements. She returned to Espiritu Santo 9 August with casualties, then loaded troops and cargo in the Russells for landing exercises on Guadalcanal. Fuller carried the same men to the assault on Peleliu on 15 September, and after offloading all her cargo and receiving casualties, sailed for Hollandia, arriving 25 September for drills in anticipation of the Leyte assault. She landed troops successfully in San Pedro Bay, Leyte, in the initial assault of 20 October, then sailed at once for Humboldt Bay to load reinforcements and supplies, with which she returned to San Pedro Bay 14 November.

Philippine Island

After preparations at Manus and New Guinea, Fuller once again launched her landing craft for the assault in Lingayen Gulf, Luzon, 9 January 1945, putting out the next day for Leyte to load reinforcements. These she landed at Lingayen, then sailed back to Leyte and on to Ulithi to load marines for exercises at Guadalcanal. Returning to Ulithi 21 March, Fuller sailed 6 days later for the invasion of Okinawa, off which she arrived during the initial landings of 1 April. However, she did not land her men until the 7th, and 2 days later she sailed for the west coast, and an overhaul completed in July. Arriving at San Pedro Bay, Leyte, 2 days after hostilities ceased, Fuller carried out occupation transport assignments until returning to Seattle, Washington, 3 December 1945.