USS Itasca or USS Itasca II has been the name of more than one United States Navy ship, and may refer to:
- USS Itasca (1861), a steamer in commission from 1861 to 1865
- USS Itasca (SP-810), later USS SP-810, a patrol boat employed as a hospital boat in commission from 1917 to 1919
- USS Itasca II (SP-803), a patrol boat in commission from 1918 to 1919
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