USS Philadelphia may refer to:

• USS Philadelphia (1776) was a gunboat built in 1776 on Lake Champlain and sunk during the Battle of Valcour Island
• USS Philadelphia (1799) was a 36-gun sailing frigate active in the Quasi-War, captured in the First Barbary War and later burned
• USS Philadelphia (1861) was a side-wheel steamer used during the American Civil War, commanded by Samuel Phillips Lee
• USS Philadelphia (C-4) was a protected cruiser commissioned in 1890 and in service until 1926
• USS Philadelphia (CL-41) was a light cruiser commissioned 1937, active in World War II, and sold to Brazil in 1951
• USS Philadelphia (SSN-690) is a Los Angeles-class attack submarine commissioned in 1977 and decommissioned in 2010