The surname Ursini may refer to:
- Fulvio Orsini or Fulvius Ursini (11 December 1529 – 18 May 1600), an Italian humanist, historian, and archaeologist
- James Ursini (born 1947), a teacher and writer living in Los Angeles
- Toma Ursini (early-17th century), an Archbishop of Antivari, Montenegro
See also
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