Van Hasselt is a Dutch-language toponymic surname, meaning "from Hasselt", a town either in Belgian Limburg, Dutch Limburg, Overijssel, the District of Kleve, or East Frisia . Notable people with this surname include the following:
- Johan Coenraad van Hasselt (1797–1823), Dutch physician, zoologist, botanist and mycologist
- André Henri Constant van Hasselt (1806–1874), Dutch-Belgian writer and poet
- Alexander Willem Michiel van Hasselt (1814–1902), Dutch entomologist and toxicologist
- Barthold Theodoor Willem van Hasselt (1896–1960), Dutch chief executive
- Dr. Sjoerd Johan van Hasselt (1992–present), Dutch biologist specialized in chronobiology and sleep research
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