Van Zile is a surname. Notable people with the name include:
- Caroline Van Zile, American lawyer and politician
- Edward Sims Van Zile (1863–1931), American writer
- Philip T. Van Zile (1843–1919), American politician and judge from Michigan
See also
- Van Zile House, 1736 house in Midland Park, Bergen County, New Jersey, United States
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