VRC may refer to:
- Vaccine Research Center
- Vancouver Rowing Club, formed in 1886
- Veteran Reserve Corps
- Victoria Racing Club
- Videogame Rating Council, rating games for Sega of America
- Virtual Radar Client, Windows radar simulator
- Vex Robotics Competition
- Great Britain Volunteer Rifle Corps of Volunteer Force
- Vulnerability and Risk Committee of the American Society of Civil Engineers
- VRChat
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