The Waccamaw were a Native American tribe of South Carolina.
Waccamaw may also refer to:
- Waccamaw Siouan Indians, a Native American Tribe of North Carolina
- Waccamaw Corp., a former home furnishings retailer
- Waccamaw River, which drains the lake
- Lake Waccamaw, a lake in North Carolina
- USS Waccamaw (AO-109), a United States Navy vessel
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