Weis, German surname, a spelling variant of Weiss, may refer to:
- Aaron and Adam Weis, American child actors and school teachers
- Al Weis (b. 1938), baseball player
- Charlie Weis (b. 1956), American football coach
- Danny Weis (b. 1948), American guitarist for Iron Butterfly and Rhinoceros
- Dominique Weis, Canadian scientist
- Frédéric Weis (b. 1977), French basketball player
- Heinz Weis (b. 1963), German athlete
- Indira Weis (b. 1979), German actress and singer
- John Ellsworth Weis (1892–1962), American painter
- Joseph F. Weis, Jr. (1923–2014), American judge
- Margaret Weis (b. 1948), American writer
- Melissa Weis (b. 1971), American discus thrower
- Petra Weis (b. 1957), German politician
- Samuel Washington Weis (1870–1956), American painter
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