Western Reserve may refer to:

• The Connecticut Western Reserve, now northeastern Ohio, U.S.
  • Western Reserve Academy, Hudson, Ohio, founded 1826
  • Western Reserve Eclectic Institute, now Hiram College, Hiram, Ohio, founded 1850
  • Western Reserve Historical Society
  • Western Reserve High School (Berlin Center, Ohio)
  • Western Reserve High School (Collins, Ohio)
  • Western Reserve Public Media and Western Reserve PBS, branding of public television stations WEAO-TV and WNEO-TV
  • Western Reserve Land Conservancy, a nonprofit land trust in Northeast Ohio
  • Case Western Reserve University, Cleveland, Ohio. Founded in 1826 as Western Reserve College and later named Western Reserve University; merged with Case Institute of Technology in 1967
  • SS Western Reserve, a ghost ship lost on Lake Superior in 1892
  • Western Reserve Hospital, a local hospital in Cuyahoga Falls, Ohio, founded 1943.
• The Manitoba West Reserve or Western Reserve in South Central Manitoba, Canada, immediately north of the American border, that was settled by Russian Mennonites beginning in 1875