Wexler is a surname of German and Yiddish origin. Notable people with the surname include:
In arts and entertainment
In film and television
- David Wexler (director) (born 1983), American filmmaker
- Eleonora Wexler, Argentine actress
- Geoffrey “Jeff” Wexler, American animation film producer and distributor
- Haskell Wexler (1922–2015), American cinematographer and director
- Karen Wexler, fictional character from the soap opera General Hospital
- Kim Wexler, fictional character from Better Call Saul
- Miriam Wexler, fictional character from Turning Red
- Norman Wexler (1926–1999), American screenwriter
- Paul Wexler (actor) (1929–1979), American actor
- Sy Wexler, American film maker
- Victor Raider-Wexler, American television and film actor
- Skyler Wexler, Canadian child actress
In other arts
- Aaron Wexler (born 1974), artist based in New York
- Dan Wexler, see Icon (band)
- Django Wexler, American fantasy writer
- Donald Wexler, American architect
- Elmer Wexler, American graphic designer
- Glen Wexler, American photographer
- Glenn Wexler, American contemporary artist
- Jerry Wexler (1917–2008), American music writer and producer
- Natalie Wexler, American novelist and historian
- Robert Freeman Wexler, American writer
In government and politics
- Anne Wexler (1930–2009), political advisor and lobbyist
- Leonard D. Wexler (1924-2018), American judge
- Max Wexler, Romanian Marxist activist
- Robert Wexler, American politician
In other fields
- Bernardo Wexler (1925–1992), chess International Master
- David B. Wexler, American law professor
- Harry Wexler (1911–1962), American meteorologist
- Jacqueline Grennan Wexler (1926-2012), American academic administrator
- Jerrold Wexler (1924–1992), American businessman
- Joan Wexler (born 1946), American Dean and President of Brooklyn Law School
- Nancy Wexler, geneticist, contributor to the identification of the gene that causes Huntington's disease
- Paul Wexler (linguist), Israeli linguist
- Robert Wexler (rabbi), university president
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