William Burke may refer to:
- William Burke (pirate) (died 1699), Irish pirate active in the Caribbean, associate of William Kidd
- William Burke (Burke and Hare murders) (1792–1829), Irish-Scots serial killer
- William Burke (author) (1729–1798), English pamphleteer
- William J. Burke (1862–1925), American politician and businessman
- William Burke (baseball) (1865–1939), 19th-century baseball player
- William L. Burke (1941–1996), astronomy, astrophysics, and physics professor at UC Santa Cruz
- William Burke Miller (1904–1983), newspaper and radio reporter
- William Burke (prior) (c. 1611–c. 1685), Irish Dominican
- William Malachy Burke (1819–1879), Irish physician and Registrar General
- William H. Burke, head coach of the College of William & Mary's football team in 1899
- William H. Burke Jr. (1906–1975), American political figure
- William mac Ulick Burke, 4th Clanricarde or Mac William Uachtar (d. 1430), Irish chieftain and noble
- William Burke, 7th Earl of Clanricarde (died 1687), Irish peer
- William Burke, Lord of Bealatury (fl. 1580s-1616), Irish noble and soldier
- Willie Burke (born 1972), former Irish footballer
- William Burke-White, American law professor and policy advisor
See also
- Billy Burke (disambiguation)
- William de Burgh (disambiguation), once used interchangeably with Burke
- William Burgh (disambiguation), once used interchangeably with Burke
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