William Cocke (1748–1828) was an American pioneer, state legislator, and U.S. senator.
William Cocke may also refer to:
- W. A. Cocke (1796–1844), mayor of Louisville, Kentucky
- William Michael Cocke (1815–1896), member of the U.S. House of Representatives from Tennessee
- William A. Cocke (1822–1887), Florida Attorney General, 1873–1876
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