William Guise was an orientalist.
William Guise may also refer to:
- Sir William Guise, 5th Baronet (1737–1783), MP for Gloucestershire
- Sir William Vernon Guise, 4th Baronet (1816–1887), of the Guise baronets
- Sir William Francis George Guise, 5th Baronet (1851–1920), of the Guise baronets
See also
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