William Mayo is the name of:
- William Benson Mayo (1866–1944), chief power engineer of the Ford Motor Company
- Two of the co-founders of the Mayo Clinic:
- William Worrall Mayo (1819–1911), British-American medical doctor and chemist, father of William James Mayo
- William James Mayo (1861–1939), American physician and surgeon
- William Leonidas Mayo (1861–1917), founder and president of East Texas Normal College
- William Starbuck Mayo (1812–1895), American doctor, traveler and writer
- William Mayo (civil engineer) (c. 1685–1744), who laid out the city of Richmond, Virginia
See also
- Bill Mayo (born 1963), American football player
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