William Nye may refer to:
- Bill Nye (William Sanford Nye, born 1955), American science educator, comedian, television host and mechanical engineer
- Will Nye, American television actor in Murder, She Wrote 1988–1991
- William Foster Nye (1824–1910), businessman who founded Nye Lubricants in 1844
- William B. Nye, former member of the 107th and 108th Ohio General Assembly 1967–1970
- William M. Nye (1829–1905), member of the Wisconsin State Assembly
- William Nye (official) (born 1966), Secretary-General of the Archbishops' Council
- William Nigh (1881–1955), American filmmaker, sometimes credited as "William Nye"
See also
- All pages with titles containing William Nye
- All pages with titles containing William Nigh
- All pages with titles containing William Nighy
- Bill Knight (disambiguation)
- Bill Nye (disambiguation)
- Bill Nigh (disambiguation)
- Bill Nighy, English actor
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