Γ-谷氨酰水解酶

Γ-谷氨酰水解酶
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1L9X
識別號
别名	GGH；, GH, gamma-glutamyl hydrolase, GATD10
外部ID	OMIM：601509 MGI：1329035 HomoloGene：2881 GeneCards：GGH
基因位置（人类）
染色体	8號染色體[1]
终止	63,039,407 bp[1]
基因位置（小鼠）
染色体	小鼠4号染色体[2]
终止	20,066,750 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• exopeptidase activity; • omega peptidase activity; • 水解酶活性; • gamma-glutamyl-peptidase activity;
細胞組分	• 黑色素体; • 细胞质基质; • 溶酶体; • 外排體; • 细胞核; • 細胞外區域; • 細胞外空間; • azurophil granule lumen; • specific granule lumen; • tertiary granule lumen; • 液胞;
生物學過程	• response to insulin; • response to zinc ion; • response to ethanol; • 蛋白酶解; • neutrophil degranulation; • tetrahydrofolylpolyglutamate metabolic process;
	Sources:Amigo / QuickGO
直系同源
	8836
	14590
	ENSG00000137563
	ENSMUSG00000073987
	Q92820
	Q9Z0L8
	NM_003878
	NM_010281
	NP_003869
	NP_034411
	維基數據

γ-谷氨酰水解酶
命名
系统命名
缩写
识别码
EC編號	3.4.19.9
CAS号	9074-87-7
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索
PMC	相关文献
PubMed	相关文献

γ-谷氨酰水解酶（英文：Gamma-glutamyl hydrolase）是一种催化以下化学反应的酶[5][6][7][8]：

γ-谷氨酰键的水解

这种溶酶体或分泌的硫醇依赖性肽酶，在酸性 pH值下最活跃。

在人类中，γ-谷氨酰水解酶由GGH基因编码。[7][9][10]该基因通过去除γ联聚谷氨酸和谷氨酸来催化叶酰聚-γ-谷氨酸和抗叶酰聚-γ-谷氨酸的水解。[10]

互动通路图

参考文献

GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. . Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n.
Yao R, Rhee MS, Galivan J. . Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632.
Yao R, Schneider E, Ryan TJ, Galivan J. . Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349 . PMID 8816764. doi:10.1073/pnas.93.19.10134 .
Yao R, Nimec Z, Ryan TJ, Galivan J. . J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .
Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. . Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5.
. [2022-12-12]. （原始内容存档于2022-12-12）.

拓展阅读

Galivan J, Ryan T, Rhee M, et al. . Semin. Oncol. 1999, 26 (2 Suppl 6): 33–7. PMID 10598552.
O'Connor BM, Rotundo RF, Nimec Z, et al. . Cancer Res. 1991, 51 (15): 3874–81. PMID 1713122.
Chandler CJ, Wang TT, Halsted CH. . J. Biol. Chem. 1986, 261 (2): 928–33. PMID 2867095. doi:10.1016/S0021-9258(17)36185-9 .
Wang TT, Chandler CJ, Halsted CH. . J. Biol. Chem. 1986, 261 (29): 13551–5. PMID 3759978. doi:10.1016/S0021-9258(18)67054-1 .
Yao R, Nimec Z, Ryan TJ, Galivan J. . J. Biol. Chem. 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .
Rhee MS, Lindau-Shepard B, Chave KJ, et al. . Mol. Pharmacol. 1998, 53 (6): 1040–6. PMID 9614206.
Li H, Ryan TJ, Chave KJ, Van Roey P. . J. Biol. Chem. 2002, 277 (27): 24522–9. PMID 11953431. doi:10.1074/jbc.M202020200 .
Strausberg RL, Feingold EA, Grouse LH, et al. . Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Basrur V, Yang F, Kushimoto T, et al. . J. Proteome Res. 2003, 2 (1): 69–79. PMID 12643545. doi:10.1021/pr025562r.
Gerhard DS, Wagner L, Feingold EA, et al. . Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
He P, Varticovski L, Bowman ED, et al. . Hum. Pathol. 2004, 35 (10): 1196–209 [2022-12-12]. PMID 15492986. doi:10.1016/j.humpath.2004.06.014. （原始内容存档于2022-10-15）.
Rual JF, Venkatesan K, Hao T, et al. . Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
Eisele LE, Chave KJ, Lehning AC, Ryan TJ. . Biochim. Biophys. Acta. 2006, 1764 (9): 1479–86. PMID 16945597. doi:10.1016/j.bbapap.2006.06.008.
Chi A, Valencia JC, Hu ZZ, et al. . J. Proteome Res. 2007, 5 (11): 3135–44. PMID 17081065. doi:10.1021/pr060363j.
Hayashi H, Fujimaki C, Inoue K, et al. . Biol. Pharm. Bull. 2007, 30 (4): 839–41. PMID 17409534. doi:10.1248/bpb.30.839 .

外部链接

醫學主題詞表（MeSH）：Gamma-glutamyl+hydrolase
PDB中UniProt可用的所有結構信息之概述：Q92820 (Gamma-glutamyl hydrolase) 在PDBe-KB。

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8343522-5] Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. . Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n.

[pmid7565632-6] Yao R, Rhee MS, Galivan J. . Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632.

[pmid8816764-7] Yao R, Schneider E, Ryan TJ, Galivan J. . Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349 . PMID 8816764. doi:10.1073/pnas.93.19.10134 .

[pmid8621474-8] Yao R, Nimec Z, Ryan TJ, Galivan J. . J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .

[pmid10570974-9] Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. . Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5.

[entrez-10] . [2022-12-12]. （原始内容存档于2022-12-12）.