乙酰胆碱酯酶
乙酰胆碱酯酶[1]（英語：，简称为，EC 3.1.1.7）是一种降解（通过其水解活性）神经递质乙酰胆碱成为胆碱和乙酸的酶。此酶類主要存在于神经肌肉接头与胆碱能神经系统中，而作用就是为了终止突触传递。乙酰胆碱酯酶具有极高的水解活性——一分子的乙酰胆碱酯酶每秒钟可以水解25000分子的乙酰胆碱。经乙酰胆碱酯酶作用而产生的胆碱被重新利用——通过重摄取被转运进入神经末梢，在那里被重新利用以合成新的乙酰胆碱分子[2]。
| 乙酰胆碱酯酶 | |||||||
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| 识别码 | |||||||
| EC編號 | 3.1.1.7 | ||||||
| CAS号 | 9000-81-1 | ||||||
| 数据库 | |||||||
| IntEnz | IntEnz浏览 | ||||||
| BRENDA | BRENDA入口 | ||||||
| ExPASy | NiceZyme浏览 | ||||||
| KEGG | KEGG入口 | ||||||
| MetaCyc | 代谢路径 | ||||||
| PRIAM | 概述 | ||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
| 基因本体 | AmiGO / EGO | ||||||
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参考文献
- Dale Purves, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White. . Sinauer Associates. 2008: 121–2. ISBN 978-0-87893-697-7.
延伸阅读
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外部链接
- ATSDR Case Studies in Environmental Medicine: Cholinesterase Inhibitors, Including Insecticides and Chemical Warfare Nerve Agents（页面存档备份，存于） U.S. Department of Health and Human Services
- Proteopedia Acetylcholinesterase
- Proteopedia AChE_inhibitors_and_substrates
- Proteopedia AChE_inhibitors_and_substrates_(Part_II)
- Proteopedia AChE bivalent inhibitors AChE_bivalent_inhibitors AChE bivalent inhibitors
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