二肽基肽酶-4

Dipeptidyl-peptidase 4
	人类DPP-4的带状结构图; 来自PDB 1PFQ.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1J2E, 1N1M, 1NU6, 1NU8, 1PFQ, 1R9M, 1R9N, 1RWQ, 1TK3, 1TKR, 1U8E, 1W1I, 1WCY, 1X70, 2AJL, 2BGN, 2BGR, 2BUB, 2FJP, 2G5P, 2G5T, 2G63, 2HHA, 2I03, 2I78, 2IIT, 2IIV, 2JID, 2OAG, 2OGZ, 2OLE, 2ONC, 2OPH, 2OQI, 2OQV, 2P8S, 2QJR, 2QKY, 2QOE, 2QT9, 2QTB, 2RGU, 2RIP, 3BJM, 3C43, 3C45, 3CCB, 3CCC, 3D4L, 3EIO, 3F8S, 3G0B, 3G0C, 3G0D, 3G0G, 3H0C, 3HAB, 3HAC, 3KWF, 3KWJ, 3NOX, 3O95, 3O9V, 3OC0, 3OPM, 3Q0T, 3Q8W, 3QBJ, 3SWW, 3SX4, 3VJK, 3VJL, 3VJM, 3W2T, 4A5S, 4DSA, 4DSZ, 4DTC, 4G1F, 4J3J, 4JH0, 4KR0, 4L72, 4LKO, 4N8D, 4N8E, 4PNZ, 4PV7, 4QZV
标识
代号	DPP4; ADABP; ADCP2; CD26; DPPIV; TP103
扩展标识	遗传学：102720 鼠基因：94919 同源基因：3279 ChEMBL: 284 GeneCards: DPP4 Gene
EC編號	3.4.14.5
基因本体论描述
分子功能	· virus receptor activity; · protease binding; · serine-type endopeptidase activity; · receptor binding; · protein binding; · serine-type peptidase activity; · dipeptidyl-peptidase activity; · identical protein binding; · protein homodimerization activity;
细胞成分	· lysosomal membrane; · plasma membrane; · focal adhesion; · cell surface; · membrane; · integral component of membrane; · apical plasma membrane; · lamellipodium; · endocytic vesicle; · lamellipodium membrane; · membrane raft; · intercellular canaliculus; · extracellular exosome; · invadopodium membrane;
生物过程	· behavioral fear response; · response to hypoxia; · proteolysis; · positive regulation of cell proliferation; · negative regulation of extracellular matrix disassembly; · T cell costimulation; · regulation of cell-cell adhesion mediated by integrin; · locomotory exploration behavior; · psychomotor behavior; · T cell activation; · endothelial cell migration; · viral entry into host cell;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

二肽基肽酶-4（英語：，DPP4）是一种人类体内的蛋白质，由DPPP4基因编码。[1]DPP4与ATRN、FAP、DPP8和DPP9有关联[2][3]。

延伸閱讀

Ansorge, S.; Bühling, F.; Kähne, T.; Lendeckel, U.; Reinhold, D.; Täger, M.; Wrenger, S. . Advances in Experimental Medicine and Biology. 1997, 421: 127–140 [2021-11-10]. ISSN 0065-2598. PMID 9330689. doi:10.1007/978-1-4757-9613-1_17. （原始内容存档于2021-11-10）. （页面存档备份，存于）
Reinhold, Dirk; Kähne, Thilo; Steinbrecher, Andreas; Wrenger, Sabine; Neubert, Klaus; Ansorge, Siegfried; Brocke, Stefan. . Biological Chemistry. 2002-07, 383 (7-8): 1133–1138 [2021-11-10]. ISSN 1431-6730. PMID 12437097. doi:10.1515/BC.2002.123. （原始内容存档于2022-04-10）. （页面存档备份，存于）
Sato, Kazuya; Dang, Nam H. . International Journal of Oncology. 2003-03, 22 (3): 481–497 [2021-11-10]. ISSN 1019-6439. PMID 12579300. （原始内容存档于2021-11-10）. （页面存档备份，存于）
De Meester, Ingrid; Lambeir, Anne-Marie; Proost, Paul; Scharpé, Simon. . Back, Nathan (编). 524. Boston, MA: Springer US. 2004: 3–17. ISBN 978-0-306-47717-1. PMID 12675218. doi:10.1007/0-306-47920-6_1.
Koch, Sina; Anthonsen, Dorit; Skovbjerg, Hanne; Sjöström, Hans. . Back, Nathan (编). 524. Boston: Kluwer Academic Publishers. 2004: 181–187. ISBN 978-0-306-47717-1. PMID 12675238. doi:10.1007/0-306-47920-6_22 （英语）.
Pro, B.; Dang, N. H. . Histology and Histopathology. 2004-10, 19 (4): 1345–1351 [2021-11-10]. ISSN 0213-3911. PMID 15375776. doi:10.14670/HH-19.1345. （原始内容存档于2022-01-20）. （页面存档备份，存于）

參考文獻

Kameoka, Junichi; Tanaka, Toshiaki; Nojima, Yoshihisa; Schlossman, Stuart F.; Morimoto, Chikao. . Science. 1993-07-23, 261 (5120): 466–469 [2021-11-10]. ISSN 0036-8075. PMID 8101391. doi:10.1126/science.8101391. （原始内容存档于2021-11-10）（英语）. （页面存档备份，存于）
. 李氏聯合診所季刊專欄. 2011-02 [2018-11-30]. （原始内容存档于2018-11-30）（中文（繁體））. （页面存档备份，存于）
Lisa AK. Mitra Assemi Betsy AC. Diabetes Mellitus. In: Koda-Kimble Mary Anne et al. Applied Therapeutics: The Clinical Use Of Drugs, 9th ed. 2009, Chap. 50.

外部連結

The MEROPS online database for peptidases and their inhibitors: S09.003
醫學主題詞表（MeSH）：Dipeptidyl-Peptidase+IV
Banting and Best Diabetes Centre at UT dpp4

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[pmid8101391-1] Kameoka, Junichi; Tanaka, Toshiaki; Nojima, Yoshihisa; Schlossman, Stuart F.; Morimoto, Chikao. . Science. 1993-07-23, 261 (5120): 466–469 [2021-11-10]. ISSN 0036-8075. PMID 8101391. doi:10.1126/science.8101391. （原始内容存档于2021-11-10）（英语）. （页面存档备份，存于）

[2] . 李氏聯合診所季刊專欄. 2011-02 [2018-11-30]. （原始内容存档于2018-11-30）（中文（繁體））. （页面存档备份，存于）

[3] Lisa AK. Mitra Assemi Betsy AC. Diabetes Mellitus. In: Koda-Kimble Mary Anne et al. Applied Therapeutics: The Clinical Use Of Drugs, 9th ed. 2009, Chap. 50.