促甲状腺激素受体
促甲状腺激素受体（英語：，TSH receptor，TSHR）又称甲促素受体，是一种接受促甲状腺激素（甲促素，thyrotropin）信号，刺激细胞生成甲状腺激素（T4）和三碘甲状腺激素（T3）的跨膜受体。TSHR是整合膜蛋白中G蛋白偶联受体超家族的一员[1]，与Gs蛋白偶合[2]。
| Thyroid stimulating hormone receptor 促甲状腺激素受体 | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | TSHR; CHNG1; LGR3; hTSHR-I | ||||||||||||
| 扩展标识 | 遗传学：603372 鼠基因：98849 同源基因：315 IUPHAR: TSH ChEMBL: 1963 GeneCards: TSHR Gene | ||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 7253 | 22095 | |||||||||||
| Ensembl | ENSG00000165409 | ENSMUSG00000020963 | |||||||||||
| UniProt | P16473 | P47750 | |||||||||||
| mRNA序列 | NM_000369 | NM_001113404 | |||||||||||
| 蛋白序列 | NP_000360 | NP_001106875 | |||||||||||
| 基因位置 |
Chr 14: 81.42 – 81.61 Mb |
Chr 12: 91.4 – 91.54 Mb | |||||||||||
| PubMed查询 | |||||||||||||
该受体主要出现在甲状腺上皮细胞的表面。
功能
在结合血循的TSH后，G蛋白信号级联反应会激活腺苷酸环化酶（adenylyl cyclase）进而使胞内环腺苷酸（cAMP）浓度升高。环腺苷酸可活化甲状腺细胞各功能层面，包括：碘泵运，甲状腺球蛋白的合成、碘化、胞吞和蛋白酶解，甲狀腺过氧化物酶活性，以及甲狀腺激素释放。
另见
参考文献
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外部链接
- . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2013-11-01）.
- 醫學主題詞表（MeSH）：Thyrotropin+Receptors
- GRIS: Glycoprotein-hormone Receptor Information System
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