免疫相关GTP酶家族M蛋白

免疫相关GTP酶家族M蛋白
識別號
别名	IRGM；, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M, immunity related GTPase M
外部ID	OMIM：608212 MGI：1926262 HomoloGene：78363 GeneCards：IRGM
相關疾病
	inflammatory bowel disease 19[1]
基因位置（人类）
染色体	5號染色體[2]
终止	150,900,736 bp[2]
基因位置（小鼠）
染色体	小鼠11号染色体[3]
终止	58,113,608 bp[3]
基因本體
分子功能	• 核苷酸結合; • GTP binding; • 水解酶活性; • 血浆蛋白结合; • protein kinase binding; • protein serine/threonine kinase activator activity; • CARD domain binding; • BH3 domain binding; • GTPase activity;
細胞組分	• phagocytic vesicle membrane; • autophagosome membrane; • cell projection; • phagocytic cup; • 细胞膜; • 膜; • cytoplasmic vesicle; • Golgi membrane; • 線粒體; • 高尔基体; • 细胞质基质; • endoplasmic reticulum membrane;
生物學過程	• 自噬; • inflammatory response; • immune system process; • autophagosome assembly; • positive regulation of protein phosphorylation; • positive regulation of autophagy; • positive regulation of peptidyl-threonine phosphorylation; • protein destabilization; • positive regulation of peptidyl-serine phosphorylation; • regulation of protein-containing complex assembly; • 先天免疫系統; • protein stabilization; • defense response to Gram-negative bacterium; • positive regulation of interferon-gamma-mediated signaling pathway; • regulation of protein complex stability; • protein lipidation involved in autophagosome assembly; • CAMKK-AMPK signaling cascade; • nucleotide-binding oligomerization domain containing 2 signaling pathway; • cellular response to lipopolysaccharide; • positive regulation of autophagosome maturation; • positive regulation of protein serine/threonine kinase activity; • defense response; • cellular response to interferon-beta;
	Sources:Amigo / QuickGO
直系同源
	345611
	54396
	ENSG00000237693
	ENSMUSG00000069874
	A1A4Y4
	Q9Z1M2
	NM_001145805; NM_001346557
	NM_019440
	NP_001139277; NP_001333486
	无数据
	維基數據

免疫相关GTP酶家族M蛋白（英語：，IRGM），亦称为干扰素诱导蛋白1（英語：，IFI1），是人体IRGM基因表达的一种酶[6]。

IRGM是干扰素诱导GTP酶家族中的分子量为47kDa的免疫相关鸟苷三磷酸酶（IRGs）成员之一。该基因编码的蛋白可能通过调控对胞内病原体的自噬形成而在先天免疫反应中发挥重要作用。

临床意义

影响该基因表达的多态性位点与克隆氏症和结核病的易感性有关[7]。

参考文献

.
GRCh38: Ensembl release 89: ENSG00000237693 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000069874 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
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Prescott, Natalie J.; Dominy, Katherine M.; Kubo, Michiaki; Lewis, Cathryn M.; Fisher, Sheila A.; Redon, Richard; Huang, Ni; Stranger, Barbara E.; Blaszczyk, Katarzyna; Hudspith, Barry; Parkes, Gareth. . Human Molecular Genetics. 2010-05-01, 19 (9) [2022-08-28]. ISSN 1460-2083. PMC 2850616 . PMID 20106866. doi:10.1093/hmg/ddq041. （原始内容存档于2023-01-18）（英语）.

深入阅读

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免疫相关GTP酶家族M蛋白引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000237693 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000069874 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-6] . （原始内容存档于2009-08-09）.

[pmid20106866-7] Prescott, Natalie J.; Dominy, Katherine M.; Kubo, Michiaki; Lewis, Cathryn M.; Fisher, Sheila A.; Redon, Richard; Huang, Ni; Stranger, Barbara E.; Blaszczyk, Katarzyna; Hudspith, Barry; Parkes, Gareth. . Human Molecular Genetics. 2010-05-01, 19 (9) [2022-08-28]. ISSN 1460-2083. PMC 2850616 . PMID 20106866. doi:10.1093/hmg/ddq041. （原始内容存档于2023-01-18）（英语）.