凝血酶
凝血酶(英語:,EC 3.4.21.5)是一种“胰蛋白酶样”丝氨酸蛋白酶蛋白质,在人体中被F2基因所编码[2][3]。在凝血作用第一级级联反应中,凝血酶原(凝血因子Ⅱ)被蛋白水解性切除以生成凝血酶,级联反应最终阻止了血液的继续流失。凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纖維蛋白原转变为不溶性的纖維蛋白,同时催化其他许多与凝血相关的反应。
另见
- 蛋白质水解图
- 纤维蛋白胶
参考文献
- PDB 2C93; Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. . J. Med. Chem. February 2006, 49 (4): 1346–55. PMID 16480269. doi:10.1021/jm050850v.
- Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. . Somat. Cell Mol. Genet. May 1987, 13 (3): 285–92. PMID 3474786. doi:10.1007/BF01535211.
- Degen SJ, Davie EW. . Biochemistry. September 1987, 26 (19): 6165–77. PMID 2825773. doi:10.1021/bi00393a033.
深入阅读
- Esmon CT. . FASEB J. 1995, 9 (10): 946–55. PMID 7615164.
- Lenting PJ, van Mourik JA, Mertens K. . Blood. 1999, 92 (11): 3983–96. PMID 9834200.
- Plow EF, Cierniewski CS, Xiao Z; et al. . Thromb. Haemost. 2002, 86 (1): 34–40. PMID 11487023.
- Maragoudakis ME, Tsopanoglou NE, Andriopoulou P. . Biochem. Soc. Trans. 2002, 30 (2): 173–7. PMID 12023846. doi:10.1042/BST0300173.
- Howell DC, Laurent GJ, Chambers RC. . Biochem. Soc. Trans. 2002, 30 (2): 211–6. PMID 12023853. doi:10.1042/BST0300211.
- Firth SM, Baxter RC. . Endocr. Rev. 2003, 23 (6): 824–54. PMID 12466191. doi:10.1210/er.2001-0033.
- Minami T, Sugiyama A, Wu SQ; et al. . Arterioscler. Thromb. Vasc. Biol. 2004, 24 (1): 41–53. PMID 14551154. doi:10.1161/01.ATV.0000099880.09014.7D.
- De Cristofaro R, De Candia E. . J. Thromb. Thrombolysis. 2004, 15 (3): 151–63. PMID 14739624. doi:10.1023/B:THRO.0000011370.80989.7b.
- Tsopanoglou NE, Maragoudakis ME. . Semin. Thromb. Hemost. 2004, 30 (1): 63–9. PMID 15034798. doi:10.1055/s-2004-822971.
- Bode W. . Blood Cells Mol. Dis. 2007, 36 (2): 122–30. PMID 16480903. doi:10.1016/j.bcmd.2005.12.027.
- Wolberg AS. . Blood Rev. 2007, 21 (3): 131–42. PMID 17208341. doi:10.1016/j.blre.2006.11.001.
- Degen S: Prothrombin. In: High K, Roberts H, eds. Molecular Basis of Thrombosis and Hemostasis. New York, NY: Marcel Dekker; 1995:75.
外部链接
- The MEROPS online database for peptidases and their inhibitors: S01.217(页面存档备份,存于)
- GeneReviews/NCBI/NIH/UW entry on Prothrombin Thrombophilia(页面存档备份,存于)
- (页面存档备份,存于) Anti-coagulation & proteases by The Proteolysis Map-animation
- PMAP: The Proteolysis Map/Thrombin
Template:凝固作用
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