抗双链DNA抗体

抗双链DNA抗体（英語：）是抗核抗体（Anti-nuclear antibody，ANA）中的一种，其靶标的抗原是双链DNA。一些血液检测如酶联免疫吸附试验（ELISA）和免疫荧光可在诊断实验室检出抗dsDNA抗体。抗dsDNA抗体在全身性紅斑狼瘡（SLE）有很高的诊断相关性，对狼瘡性腎炎的发病机制有重要作用[1][2]。

抗双链DNA抗体的免疫荧光染色图：左，HEp-20-10细胞；中，绿蝇短膜虫；右，大鼠肝脏

在疾病中的作用

参考文献

Kavanaugh A, Tomar R, Reveille J, Solomon DH, Homburger HA. . Arch. Pathol. Lab. Med. January 2000, 124 (1): 71–81. PMID 10629135. doi:10.1043/0003-9985(2000)124<0071:GFCUOT>2.0.CO;2.
Mortensen ES, Fenton KA, Rekvig OP. . Am. J. Pathol. February 2008, 172 (2): 275–83. PMC 2312358 . PMID 18187568. doi:10.2353/ajpath.2008.070563.

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[pmid10629135-1] Kavanaugh A, Tomar R, Reveille J, Solomon DH, Homburger HA. . Arch. Pathol. Lab. Med. January 2000, 124 (1): 71–81. PMID 10629135. doi:10.1043/0003-9985(2000)124<0071:GFCUOT>2.0.CO;2.

[pmid2312358-2] Mortensen ES, Fenton KA, Rekvig OP. . Am. J. Pathol. February 2008, 172 (2): 275–83. PMC 2312358 . PMID 18187568. doi:10.2353/ajpath.2008.070563.