普列克底物蛋白

普列克底物蛋白
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2I5C、2I5F、2CSO、1W4M、1XX0、1PLS、1X05、1ZM0
識別號
别名	PLEK；, Pleckstrin, pleckstrin, P47
外部ID	OMIM：173570 MGI：1860485 HomoloGene：2000 GeneCards：PLEK
相關疾病
	乳糜泻[1]
基因位置（人类）
染色体	2號染色體[2]
终止	68,397,453 bp[2]
基因位置（小鼠）
染色体	小鼠11号染色体[3]
终止	17,002,381 bp[3]
基因本體
分子功能	• protein homodimerization activity; • phosphatidylinositol-3,4-bisphosphate binding; • 血浆蛋白结合; • protein kinase C binding;
細胞組分	• 細胞質; • 细胞质基质; • 膜; • ruffle membrane; • 細胞外區域;
生物學過程	• actin cytoskeleton reorganization; • thrombin-activated receptor signaling pathway; • intracellular signal transduction; • phospholipase C-inhibiting G protein-coupled receptor signaling pathway; • phosphatidylinositol metabolic process; • regulation of cell diameter; • ruffle organization; • platelet degranulation; • positive regulation of integrin activation; • protein kinase C signaling; • vesicle docking involved in exocytosis; • positive regulation of inositol-polyphosphate 5-phosphatase activity; • cell projection organization; • hematopoietic progenitor cell differentiation; • integrin-mediated signaling pathway; • negative regulation of calcium-mediated signaling; • positive regulation of actin filament bundle assembly; • protein secretion by platelet; • negative regulation of G protein-coupled receptor signaling pathway; • platelet aggregation; • cortical actin cytoskeleton organization; • positive regulation of platelet activation; • positive regulation of actin filament depolymerization; • negative regulation of inositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	5341
	56193
	ENSG00000115956
	ENSMUSG00000020120
	P08567
	Q9JHK5
	NM_002664
	NM_019549
	NP_002655
	NP_062422
	維基數據

普列克底物蛋白（）是一个发现于血小板的蛋白。其命名中“plec”来源于血小板及白细胞C激酶底物（platelet and leukocyte C kinase substrate），“kstr”来自于氨基酸序列KSTR（赖氨酸-丝氨酸-苏氨酸-精氨酸）。

此名词是PH结构域（pleckstrin 同源结构域，pleckstrin homology domain）和DEP结构域（Dishevelled, Egl-10 and Pleckstrin domain，DEP domain）的词源。

中文暂名：普列克底物蛋白

参考文献

.
GRCh38: Ensembl release 89: ENSG00000115956 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020120 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.

外部链接

醫學主題詞表（MeSH）：pleckstrin

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000115956 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000020120 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.