治療藥物監控

治療藥物監控(Therapeutic drug monitoring）是临床化学的一个分支，研究檢驗藥物血濃度以確保藥效與預防毒性產生。治療藥物監控主要关注那些治療濃度與毒性濃度非常接近的藥物。

基本觀念

Bioavailability (F) 生體可用率
Administration Rate (RA) 給藥速率
Desired Plasma Concentration (C) 目標濃度
Volume of Distribution (V) 分布體積
Clearance (Cl) 廓清率
Elimination Rate Constant (K) 排除速率常數與 Half-Life (T1/2) 半衰期
Maximum Minimum Plasma Concentration 最高/最低濃度
Selecting the appropriate Equation 選用適當的計算方法
Interpretation of Plasma Drug Concentrations 解讀藥物血中濃度的意義
Creatinine Clearance (Clcr) 肌酐酸廓清率
Dialysis of Drugs 血液透析與藥物

臨床上常監控的藥品

Aminoglycoside antibiotics
Digoxin
Immunosuppressants
Phenytoin
Valproic acid
Vancomycin

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