猪笼草蛋白酶
猪笼草蛋白酶(Nepenthesin,Nepenthacin[1][2],Nepenthasin[3]),又称猪笼草酸性蛋白酶,猪笼草天冬氨酸蛋白酶[3]是猪笼草捕虫笼及盾叶茅膏菜(Drosera peltata)分泌的天冬氨酸蛋白酶。[4][5][6][7][8][9]其与胃蛋白酶类似,但其也能酶切两侧的天冬氨酸残基及赖氨酸┼精氨酸。[3]其对pH值及温度的稳定性高于猪胃蛋白酶A,对尿素及盐酸胍的稳定性大大降低。[10]
猪笼草蛋白酶 | |||||||
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识别码 | |||||||
EC編號 | 3.4.23.12 | ||||||
CAS号 | 9073-80-7 | ||||||
数据库 | |||||||
IntEnz | IntEnz浏览 | ||||||
BRENDA | BRENDA入口 | ||||||
ExPASy | NiceZyme浏览 | ||||||
KEGG | KEGG入口 | ||||||
MetaCyc | 代谢路径 | ||||||
PRIAM | 概述 | ||||||
PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
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1968年,Shigeru Nakayama和Shizuko Amagase以“nepenthesin”命名猪笼草蛋白酶。[11]在猪笼草属中已确定了2个同工酶:猪笼草蛋白酶I与猪笼草蛋白酶II。[12]
参考文献
- Jentsch J. . FEBS Lett. April 1972, 21 (3): 273–276. PMID 11946525. doi:10.1016/0014-5793(72)80181-9.
- Jentsch J, Meierkord S, Hammer M. . Planta Medica. 1989, 55: 227. doi:10.1055/s-2006-961979.
- EC 3.4.23.12 - Nepenthesin (页面存档备份,存于). Integrated Enzyme Database (IntEnz).
- Amagase S, Nakayama S, Tsugita A. . J. Biochem. October 1969, 66 (4): 431–9. PMID 5354017.
- Amagase S. . J. Biochem. July 1972, 72 (1): 73–81. PMID 5069751.
- Amagase S, Mori M, Nakayama S. . J. Biochem. September 1972, 72 (3): 765–7. PMID 4634982.
- Tökés ZA, Woon WC, Chambers SM. . Planta. March 1974, 119 (1): 39–46. doi:10.1007/BF00390820.
- Athauda SBP, Inoue H, Iwamatsu A, Takahashi K. . James, Michael (编). . New York: Plenum. 1998: 453–458. ISBN 0-306-45809-8.
- Takahashi K, Tanji M, Shibata C. (PDF). Carnivorous Plant News Letter. 2007, 36 (3): 73–76 [2011-12-10]. (原始内容存档 (PDF)于2012-02-27).
- Kubota K, Metoki Y, Athauda SBP, Shibata C, Takahashi K. . Bioscience, Biotechnology, and Biochemistry. 2010, 74 (11): 2323–2326. doi:10.1271/bbb.100391.
- Nakayama S, Amagase S. . Proceedings of the Japan Academy. 1968, 44 (5): 358–362.
- Athauda SB, Matsumoto K, Rajapakshe S, Kuribayashi M, Kojima M, Kubomura-Yoshida N, Iwamatsu A, Shibata C, Inoue H, Takahashi K. . Biochem. J. July 2004, 381 (Pt 1): 295–306. PMC 1133788 . PMID 15035659. doi:10.1042/BJ20031575.
扩展阅读
- The MEROPS online database for peptidases and their inhibitors: A01.040
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