白细胞介素-6

白细胞介素-6（），简称白介素-6（IL-6，在人体内由IL6基因编码[5]），最初由日本免疫学家岸本忠三团队发现[6]，是一种介导炎症的白细胞介素（但在某些情况下也具有抗炎症作用）[7][5]。白细胞介素-6可由T细胞、B细胞、单核细胞、成纤维细胞、角质形成细胞、内皮细胞、系膜细胞，以及一部分肿瘤细胞分泌[8]。

白細胞介素6
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 4O9H、​1ALU、​1IL6、​1P9M、​2IL6、​4CNI、​4J4L、​4NI7、​4NI9、​4ZS7
識別號
别名	IL6；, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
外部ID	OMIM：147620 MGI：96559 HomoloGene：502 GeneCards：IL6
基因位置（人类） 染色体 7號染色體[1] 基因座 7p15.3 起始 22,725,884 bp[1] 终止 22,732,002 bp[1]
基因位置（小鼠） 染色体 小鼠5号染色体[2] 基因座 5 B1|5 15.7 cM 起始 30,218,112 bp[2] 终止 30,224,979 bp[2]
RNA表达模式
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基因本體 分子功能 • 細胞因子活性 • 生長因子活性 • interleukin-6 receptor binding • 血浆蛋白结合 細胞組分 • 細胞外區域 • interleukin-6 receptor complex • 細胞外空間 • endoplasmic reticulum lumen 生物學過程 • regulation of angiogenesis • positive regulation of translation • platelet activation • humoral immune response • defense response to virus • response to peptidoglycan • neuron projection development • defense response to Gram-positive bacterium • negative regulation of fat cell differentiation • positive regulation of peptidyl-serine phosphorylation • positive regulation of leukocyte chemotaxis • positive regulation of T cell proliferation • positive regulation of interleukin-6 production • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of acute inflammatory response • inflammatory response • negative regulation of collagen biosynthetic process • positive regulation of MAPK cascade • hepatic immune response • monocyte chemotaxis • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • positive regulation of osteoblast differentiation • positive regulation of NF-kappaB transcription factor activity • 急性期反应 • 免疫反应 • regulation of vascular endothelial growth factor production • positive regulation of chemokine production • negative regulation of lipid storage • neutrophil mediated immunity • positive regulation of smooth muscle cell proliferation • positive regulation of type B pancreatic cell apoptotic process • response to glucocorticoid • defense response to Gram-negative bacterium • positive regulation of cell population proliferation • positive regulation of apoptotic process • positive regulation of B cell activation • 翻译后修饰 • regulation of signaling receptor activity • positive regulation of tyrosine phosphorylation of STAT protein • neutrophil apoptotic process • negative regulation of cell population proliferation • positive regulation of gene expression • endocrine pancreas development • negative regulation of bone resorption • positive regulation of transcription, DNA-templated • positive regulation of transcription by RNA polymerase II • glucagon secretion • cellular response to hydrogen peroxide • cellular response to lipopolysaccharide • T-helper 17 cell lineage commitment • positive regulation of T-helper 2 cell cytokine production • negative regulation of interleukin-1-mediated signaling pathway • cytokine-mediated signaling pathway • interleukin-6-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • 訊息傳遞 Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3569	16193
Ensembl	ENSG00000136244	ENSMUSG00000025746
UniProt	P05231	P08505
mRNA​序列	NM_000600 ​NM_001318095 ​NM_001371096	NM_031168 ​NM_001314054
蛋白序列	NP_000591 ​NP_001305024 ​NP_001358025	NP_001300983 ​NP_112445
基因位置​（UCSC）	Chr 7: 22.73 – 22.73 Mb	Chr 5: 30.22 – 30.22 Mb
PubMed​查找	[3]	[4]
維基數據

白细胞介素-6最初被认为是一种能促进B细胞分化为浆细胞的因子，后来陆续发现有其他功能[9]。 例如，白细胞介素-6能够穿过血脑屏障[10]，与中枢神经系统的正常生理过程与损伤修复过程都有关联[9]。