突觸素
突觸素(Synaptophysin),又稱主要突觸小泡蛋白p38(major synaptic vesicle protein p38),是一種人體中由「SYP」基因轉譯而成的蛋白質[6][7]。
分子生物學
該蛋白質為突触小泡上的醣蛋白,擁有四個穿膜區。該蛋白主要表現於神經內分泌細胞,基本上只要擁有突觸傳輸功能的神經元皆會表達。在免疫染色組織學上,該蛋白常被作為神經內分泌腫瘤的標誌蛋白,或是用於突觸豐度的定量[8]。
目前該蛋白的確切功能尚未闡明,僅知他會與重要的突觸蛋白synaptobrevin產生交互作用。但在動物實驗中,即使將突觸素的基因敲除,似乎並沒有對動物的發育或功能上產生任何影響[9]。近期研究顯示,突觸素的缺失可能導致小鼠出現行為異常,例如探索行為增加、新奇物辨識(object novelty recognition),以及空間感上產生影響[10]。
參見
- 人類基因列表
參考文獻
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- GRCh38: Ensembl release 89: ENSG00000102003 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000031144 - Ensembl, May 2017
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