组织蛋白酶V

组织蛋白酶V
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1FH0、3H6S、3KFQ
識別號
别名	CTSV；, cathepsin V, CATL2, CTSL2, CTSU
外部ID	OMIM：603308 MGI：88564 HomoloGene：76699 GeneCards：CTSV
基因位置（人类）
染色体	9號染色體[1]
终止	97,156,556 bp[1]
基因位置（小鼠）
染色体	小鼠13号染色体[2]
终止	64,518,704 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 半胱氨酸型肽酶活性; • peptide binding; • 肽酶活性; • 血浆蛋白结合; • aminopeptidase activity; • 水解酶活性; • serine-type endopeptidase activity; • cysteine-type endopeptidase activity; • cysteine-type carboxypeptidase activity; • histone binding; • kininogen binding; • 大分子复合物结合;
細胞組分	• 細胞質; • 細胞本體; • apical part of cell; • secretory granule; • 細胞外區域; • 微绒毛; • 液胞; • lysosomal lumen; • neuron projection; • 溶酶体; • external side of plasma membrane; • 細胞外空間; • 细胞核; • 核仁; • cytoplasmic vesicle;
生物學過程	• male gonad development; • response to organic cyclic compound; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • cellular response to starvation; • extracellular matrix disassembly; • response to glucocorticoid; • response to glucose; • Sertoli cell differentiation; • response to gonadotropin; • 蛋白酶解; • cell communication; • 蛻膜化; • 精子发生; • multicellular organism aging; • proteolysis involved in cellular protein catabolic process; • nerve development; • autophagic cell death; • response to odorant; • regulation of keratinocyte differentiation; • negative regulation of keratinocyte proliferation; • protein processing; • protein autoprocessing; • hair follicle morphogenesis; • regulation of actin cytoskeleton reorganization;
	Sources:Amigo / QuickGO
直系同源
	1515
	13039
	ENSG00000136943
	ENSMUSG00000021477
	O60911
	P06797
	NM_001333; NM_001201575
	NM_009984
	NP_001188504; NP_001324
	NP_034114
	維基數據

组织蛋白酶V, （EC 3.4.22.43，也被称为组织蛋白酶L2或组织蛋白酶U），是一种在人类中由CTSV基因编码的蛋白质。[5][6][7][8]

该蛋白质是木瓜蛋白酶样蛋白酶家族（MEROPS家族C1）的成员，这是一种具有内肽酶活性的溶酶体半胱氨酸蛋白酶。它可能在角膜生理学中起重要作用。该基因在结肠直肠癌和乳癌中表达，但在正常结肠、乳腺或肿瘤周围组织中不表达，这表明该基因在肿瘤过程中可能发挥作用。

临床意义

组织蛋白酶V可能在圆锥角膜的发病机制中发挥作用。[9]

参考文献

GRCh38: Ensembl release 89: ENSG00000136943 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021477 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
.
Brömme D, Li Z, Barnes M, Mehler E. . Biochemistry. February 1999, 38 (8): 2377–85. PMID 10029531. doi:10.1021/bi982175f.
Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K. . Investigative Ophthalmology & Visual Science. September 1998, 39 (10): 1789–96. PMID 9727401.
Santamaría I, Velasco G, Cazorla M, Fueyo A, Campo E, López-Otín C. . Cancer Research. April 1998, 58 (8): 1624–30. PMID 9563472.
Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ. . Invest. Ophthalmol. Vis. Sci. 2005, 46 (3): 823–832. PMID 15728537. doi:10.1167/iovs.04-0549 .

阅读

Santamaría I, Velasco G, Cazorla M, et al. . Cancer Res. 1998, 58 (8): 1624–30. PMID 9563472.
Adachi W, Kawamoto S, Ohno I, et al. . Invest. Ophthalmol. Vis. Sci. 1998, 39 (10): 1789–96. PMID 9727401.
Brömme D, Li Z, Barnes M, Mehler E. . Biochemistry. 1999, 38 (8): 2377–85. PMID 10029531. doi:10.1021/bi982175f.
Itoh R, Kawamoto S, Adachi W, et al. . DNA Res. 1999, 6 (2): 137–40. PMID 10382972. doi:10.1093/dnares/6.2.137 .
Somoza JR, Zhan H, Bowman KK, et al. . Biochemistry. 2000, 39 (41): 12543–51. PMID 11027133. doi:10.1021/bi000951p.
Strausberg RL, Feingold EA, Grouse LH, et al. . Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
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Tolosa E, Li W, Yasuda Y, et al. . J. Clin. Invest. 2003, 112 (4): 517–26. PMC 171390 . PMID 12925692. doi:10.1172/JCI18028.
Clark HF, Gurney AL, Abaya E, et al. . Genome Res. 2003, 13 (10): 2265–70. PMC 403697 . PMID 12975309. doi:10.1101/gr.1293003.
Humphray SJ, Oliver K, Hunt AR, et al. . Nature. 2004, 429 (6990): 369–74. Bibcode:2004Natur.429..369H. PMC 2734081 . PMID 15164053. doi:10.1038/nature02465.
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外部链接

The MEROPS online database for peptidases and their inhibitors: C01.009 （页面存档备份，存于）
醫學主題詞表（MeSH）：Cathepsin+V

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136943 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021477 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] .

[6] Brömme D, Li Z, Barnes M, Mehler E. . Biochemistry. February 1999, 38 (8): 2377–85. PMID 10029531. doi:10.1021/bi982175f.

[7] Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K. . Investigative Ophthalmology & Visual Science. September 1998, 39 (10): 1789–96. PMID 9727401.

[8] Santamaría I, Velasco G, Cazorla M, Fueyo A, Campo E, López-Otín C. . Cancer Research. April 1998, 58 (8): 1624–30. PMID 9563472.

[Kenney05-9] Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ. . Invest. Ophthalmol. Vis. Sci. 2005, 46 (3): 823–832. PMID 15728537. doi:10.1167/iovs.04-0549 .