血管活性腸肽

血管活性腸肽
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2RRI、2RRH
識別號
别名	VIP；, vasoactive intestinal peptide, PHM27
外部ID	OMIM：192320 MGI：98933 HomoloGene：2539 GeneCards：VIP
基因位置（人类）
染色体	6號染色體[1]
终止	152,759,765 bp[1]
基因位置（小鼠）
染色体	小鼠10号染色体[2]
终止	5,597,617 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• hormone activity; • 血浆蛋白结合; • neuropeptide hormone activity; • peptide hormone receptor binding;
細胞組分	• 細胞外區域; • 胞內; • neuron projection; • 細胞本體;
生物學過程	• G protein-coupled receptor signaling pathway; • body fluid secretion; • prolactin secretion; • mRNA stabilization; • positive regulation of cell population proliferation; • 先天免疫系統; • positive regulation of protein catabolic process; • regulation of protein localization; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of endothelial cell proliferation; • 学习和记忆; • positive regulation of epinephrine secretion; • negative regulation of apoptotic process; • negative regulation of potassium ion transport; • epinephrine secretion; • 平滑肌細胞增殖的負調控; • regulation of sensory perception of pain; • positive regulation of penile erection; • phospholipase C-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	7432
	22353
	ENSG00000146469
	ENSMUSG00000019772
	P01282
	P32648
	NM_003381; NM_194435
	NM_011702; NM_001313969
	NP_003372; NP_919416
NP_001300898; NP_035832; NP_001394459; NP_001394460; NP_001394461;
	NP_001394462; NP_001394463
	維基數據

血管活性腸肽（），常簡稱VIP，屬於一種可促進腸道血管活性的肽类激素，由28個氨基酸殘基組成。本蛋白屬於升糖素/胰泌素超家族，為第二型G蛋白偶联受体的配體[5]。VIP在許多脊椎動物身上皆存在，包含腸、胰脏，以及下視丘視上核[6][7][8]。VIP能刺激心臟收縮力、血管舒張、增加糖原分解、降低動脈血壓，以及促進氣管、胃、膽囊平滑肌舒張。在人類體內，該蛋白的編碼基因為「VIP」[9]

VIP在血中的半衰期（t_½）約兩分鐘[10]。

參考文獻

血管活性腸肽受體
VPAC1
VPAC2

參考文獻

GRCh38: Ensembl release 89: ENSG00000146469 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019772 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Umetsu Y, Tenno T, Goda N, Shirakawa M, Ikegami T, Hiroaki H. . Biochimica et Biophysica Acta. May 2011, 1814 (5): 724–30. PMID 21439408. doi:10.1016/j.bbapap.2011.03.009.
Juhász T, Helgadottir SL, Tamás A, Reglődi D, Zákány R. . Peptides. April 2015, 66: 51–7. PMID 25701761. doi:10.1016/j.peptides.2015.02.001.
Delgado M, Ganea D. . Amino Acids. July 2013, 45 (1): 25–39. PMC 3883350 . PMID 22139413. doi:10.1007/s00726-011-1184-8.
Fahrenkrug J. . Results and Problems in Cell Differentiation. 2010-01-01, 50: 221–34. PMID 19859678. doi:10.1007/400_2009_24.
Hahm SH, Eiden LE. . Annals of the New York Academy of Sciences. December 1998, 865: 10–26. PMID 9927992.
Henning RJ, Sawmiller DR. . Cardiovascular Research. January 2001, 49 (1): 27–37. PMID 11121793.

延伸閱讀

Watanabe J. . Handbook of Hormones (Academic Press). 1 January 2016: 150–e18E–10. doi:10.1016/b978-0-12-801028-0.00146-x.
Fahrenkrug J. . Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum. 2001, 234: 35–9. PMID 11713978.
Delgado M, Pozo D, Ganea D. . Pharmacological Reviews. June 2004, 56 (2): 249–90. PMID 15169929. doi:10.1124/pr.56.2.7.
Conconi MT, Spinazzi R, Nussdorfer GG. . International Review of Cytology. 2006, 249: 1–51. ISBN 978-0-12-364653-8. PMID 16697281. doi:10.1016/S0074-7696(06)49001-X.
Hill JM. . Current Pharmaceutical Design. 2007, 13 (11): 1079–89. PMID 17430171. doi:10.2174/138161207780618975.
Gonzalez-Rey E, Varela N, Chorny A, Delgado M. . Current Pharmaceutical Design. 2007, 13 (11): 1113–39. PMID 17430175. doi:10.2174/138161207780618966.
Glowa JR, Panlilio LV, Brenneman DE, Gozes I, Fridkin M, Hill JM. . Brain Research. January 1992, 570 (1-2): 49–53. PMID 1617429. doi:10.1016/0006-8993(92)90562-n.
Theriault Y, Boulanger Y, St-Pierre S. . Biopolymers. March 1991, 31 (4): 459–64. PMID 1863695. doi:10.1002/bip.360310411.
Gozes I, Giladi E, Shani Y. . Journal of Neurochemistry. April 1987, 48 (4): 1136–41. PMID 2434617. doi:10.1111/j.1471-4159.1987.tb05638.x.
Yamagami T, Ohsawa K, Nishizawa M, Inoue C, Gotoh E, Yanaihara N, Yamamoto H, Okamoto H. . Annals of the New York Academy of Sciences. 1988, 527: 87–102. PMID 2839091. doi:10.1111/j.1749-6632.1988.tb26975.x.
DeLamarter JF, Buell GN, Kawashima E, Polak JM, Bloom SR. . Peptides. 1985,. 6 Suppl 1 (Suppl 1): 95–102. PMID 2995945. doi:10.1016/0196-9781(85)90016-6.
Linder S, Barkhem T, Norberg A, Persson H, Schalling M, Hökfelt T, Magnusson G. . Proceedings of the National Academy of Sciences of the United States of America. January 1987, 84 (2): 605–9. PMC 304259 . PMID 3025882. doi:10.1073/pnas.84.2.605.
Gozes I, Bodner M, Shani Y, Fridkin M. . Peptides. 1986,. 7 Suppl 1 (Suppl 1): 1–6. PMID 3748844. doi:10.1016/0196-9781(86)90156-7.
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外部連結

Pathway at biocarta.com （页面存档备份，存于）
MCG生理学 6/6ch2/s6ch2_34

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146469 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019772 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Umetsu Y, Tenno T, Goda N, Shirakawa M, Ikegami T, Hiroaki H. . Biochimica et Biophysica Acta. May 2011, 1814 (5): 724–30. PMID 21439408. doi:10.1016/j.bbapap.2011.03.009.

[6] Juhász T, Helgadottir SL, Tamás A, Reglődi D, Zákány R. . Peptides. April 2015, 66: 51–7. PMID 25701761. doi:10.1016/j.peptides.2015.02.001.

[7] Delgado M, Ganea D. . Amino Acids. July 2013, 45 (1): 25–39. PMC 3883350 . PMID 22139413. doi:10.1007/s00726-011-1184-8.

[8] Fahrenkrug J. . Results and Problems in Cell Differentiation. 2010-01-01, 50: 221–34. PMID 19859678. doi:10.1007/400_2009_24.

[9] Hahm SH, Eiden LE. . Annals of the New York Academy of Sciences. December 1998, 865: 10–26. PMID 9927992.

[10] Henning RJ, Sawmiller DR. . Cardiovascular Research. January 2001, 49 (1): 27–37. PMID 11121793.