黑素皮质素受体4

黑素皮质素受体4
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2IQP、2IQR、2IQS、2IQU、2IQV、2IQW
識別號
别名	MC4R；, Melanocortin 4 receptor, BMIQ20
外部ID	OMIM：155541 MGI：99457 HomoloGene：4320 GeneCards：MC4R
相關疾病
	兒童肥胖、体重[1]
為以下藥物的標靶
	美拉諾坦 I、美拉諾坦 II、THIQ、setmelanotide[2]
基因位置（人类）
染色体	18號染色體[3]
终止	60,372,775 bp[3]
基因位置（小鼠）
染色体	小鼠18号染色体[4]
终止	66,993,577 bp[4]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled receptor activity; • signal transducer activity; • peptide hormone binding; • melanocyte-stimulating hormone receptor activity; • 血浆蛋白结合; • melanocortin receptor activity; • 泛素蛋白连接酶结合; • neuropeptide binding; • hormone binding;
細胞組分	• integral component of membrane; • 膜; • 细胞膜; • 细胞核;
生物學過程	• regulation of grooming behavior; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • insulin secretion; • regulation of feeding behavior; • positive regulation of bone resorption; • diet induced thermogenesis; • response to insulin; • feeding behavior; • negative regulation of feeding behavior; • energy reserve metabolic process; • regulation of metabolic process; • 訊息傳遞; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	4160
	17202
	ENSG00000166603
	ENSMUSG00000047259
	P32245
	P56450
	NM_005912
	NM_016977
	NP_005903
	NP_058673
	維基數據

MC4受體，即MC4R，是在人體中由MC4R基因編碼的黑素皮质素受體[7][8][9]。它編碼MC4蛋白。在小鼠中，已發現MC4受體參與進食行為，代謝，性行為和男性勃起功能的調節[10][11][12]。

據2008年的報導，MC4R突變與人類遺傳性肥胖有關[13]。在體重指數大於30的人群中，該病的患病率為1.0–2.5％，是最容易導致肥胖的最常見遺傳缺陷。

參考文獻

.
.
GRCh38: Ensembl release 89: ENSG00000166603 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047259 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Magenis RE, Smith L, Nadeau JH, Johnson KR, Mountjoy KG, Cone RD. . Mammalian Genome. August 1994, 5 (8): 503–8. PMID 7949735. doi:10.1007/BF00369320.
Sundaramurthy D, Campbell DA, Leek JP, Markham AF, Pieri LF. . Cytogenetics and Cell Genetics. November 1998, 82 (1–2): 97–8. PMID 9763669. doi:10.1159/000015074.
. （原始内容存档于2010-03-07）.
Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. . Nature. January 1997, 385 (6612): 165–8. Bibcode:1997Natur.385..165F. PMID 8990120. doi:10.1038/385165a0.
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. . Cell. January 1997, 88 (1): 131–41. PMID 9019399. doi:10.1016/S0092-8674(00)81865-6.
Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, et al. . Proceedings of the National Academy of Sciences of the United States of America. August 2002, 99 (17): 11381–6. Bibcode:2002PNAS...9911381V. PMC 123265 . PMID 12172010. doi:10.1073/pnas.172378699.
Loos, Ruth J. F.; Lindgren, Cecilia M.; Li, Shengxu; Wheeler, Eleanor; Zhao, Jing Hua; Prokopenko, Inga; Inouye, Michael; Freathy, Rachel M.; Attwood, Antony P.; Beckmann, Jacques S.; Berndt, Sonja I. . Nature Genetics. June 2008, 40 (6): 768–775. ISSN 1546-1718. PMC 2669167 . PMID 18454148. doi:10.1038/ng.140.

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[1] .

[2] .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000166603 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000047259 - Ensembl, May 2017

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7949735-7] Magenis RE, Smith L, Nadeau JH, Johnson KR, Mountjoy KG, Cone RD. . Mammalian Genome. August 1994, 5 (8): 503–8. PMID 7949735. doi:10.1007/BF00369320.

[pmid9763669-8] Sundaramurthy D, Campbell DA, Leek JP, Markham AF, Pieri LF. . Cytogenetics and Cell Genetics. November 1998, 82 (1–2): 97–8. PMID 9763669. doi:10.1159/000015074.

[9] . （原始内容存档于2010-03-07）.

[10] Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. . Nature. January 1997, 385 (6612): 165–8. Bibcode:1997Natur.385..165F. PMID 8990120. doi:10.1038/385165a0.

[11] Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. . Cell. January 1997, 88 (1): 131–41. PMID 9019399. doi:10.1016/S0092-8674(00)81865-6.

[12] Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, et al. . Proceedings of the National Academy of Sciences of the United States of America. August 2002, 99 (17): 11381–6. Bibcode:2002PNAS...9911381V. PMC 123265 . PMID 12172010. doi:10.1073/pnas.172378699.

[13] Loos, Ruth J. F.; Lindgren, Cecilia M.; Li, Shengxu; Wheeler, Eleanor; Zhao, Jing Hua; Prokopenko, Inga; Inouye, Michael; Freathy, Rachel M.; Attwood, Antony P.; Beckmann, Jacques S.; Berndt, Sonja I. . Nature Genetics. June 2008, 40 (6): 768–775. ISSN 1546-1718. PMC 2669167 . PMID 18454148. doi:10.1038/ng.140.