钙蛋白酶2催化亚基

钙蛋白酶2催化亚基
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1KFU、1KFX、2NQA
識別號
别名	CAPN2；, CANP2, CANPL2, CANPml, mCANP, calpain 2
外部ID	OMIM：114230 MGI：88264 HomoloGene：1326 GeneCards：CAPN2
基因位置（人类）
染色体	1號染色體[1]
终止	223,776,018 bp[1]
基因位置（小鼠）
染色体	小鼠1号染色体[2]
终止	182,345,173 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• calcium ion binding; • 半胱氨酸型肽酶活性; • 金屬離子結合; • cytoskeletal protein binding; • 肽酶活性; • 血浆蛋白结合; • protein heterodimerization activity; • 水解酶活性; • calcium-dependent cysteine-type endopeptidase activity; • 酶结合;
細胞組分	• 高尔基体; • 偽足; • 膜; • 粘着斑; • perinuclear endoplasmic reticulum; • 胞內; • 树突; • 内质网; • cortical actin cytoskeleton; • 脂筏模型; • 染色质; • 溶酶体; • 外排體; • 细胞核; • 细胞质基质; • 細胞質; • 细胞膜; • mitochondrial intermembrane space; • external side of plasma membrane; • cell projection; • neuronal cell body;
生物學過程	• response to hypoxia; • protein autoprocessing; • 蛋白酶解; • cellular response to amino acid stimulus; • myoblast fusion; • proteolysis involved in cellular protein catabolic process; • regulation of cytoskeleton organization; • blastocyst development; • extracellular matrix disassembly; • female pregnancy; • positive regulation of cardiac muscle cell apoptotic process; • regulation of interleukin-6 production; • cellular response to interferon-beta; • response to hydrogen peroxide; • behavioral response to pain; • cellular response to lipopolysaccharide; • positive regulation of neuron death; • positive regulation of myoblast fusion; • positive regulation of phosphatidylcholine biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	824
	12334
	ENSG00000162909
	ENSMUSG00000026509
	P17655
	O08529
	NM_001146068; NM_001748
	NM_009794
	NP_001139540; NP_001739
	NP_033924
	維基數據

钙蛋白酶2催化亚基（英语：Calpain-2 catalytic subunit）是人类中由CAPN2基因编码的蛋白质。[5][6]

功能

钙蛋白酶是钙激活的中性蛋白酶，是非溶酶体的细胞内半胱氨酸蛋白酶。哺乳动物钙蛋白酶包括普遍存在的胃特异性和肌肉特异性蛋白质。普遍存在的酶由异二聚体组成，这些异二聚体具有与常见的小调节亚基相关的独特的大催化亚基。该基因编码普遍存在的酶钙蛋白酶2的大亚基。已报道5' UTR中存在多个异质转录起始位点。[7]

相互作用

CAPN2已被证明与Bcl-2产生相互作用。[8]

参考资料

GRCh38: Ensembl release 89: ENSG00000162909 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026509 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
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Hata A, Ohno S, Akita Y, Suzuki K. . J. Biol. Chem. May 1989, 264 (11): 6404–11. PMID 2539381. doi:10.1016/S0021-9258(18)83364-6 .
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外部链接

The MEROPS online database for peptidases and their inhibitors: C02.002
Human CAPN2 genome location and CAPN2 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162909 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026509 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2852952-5] Imajoh S, Aoki K, Ohno S, Emori Y, Kawasaki H, Sugihara H, Suzuki K. . Biochemistry. 1988, 27 (21): 8122–8. PMID 2852952. doi:10.1021/bi00421a022.

[pmid2539381-6] Hata A, Ohno S, Akita Y, Suzuki K. . J. Biol. Chem. May 1989, 264 (11): 6404–11. PMID 2539381. doi:10.1016/S0021-9258(18)83364-6 .

[entrez-7] .

[pmid12000759-8] Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W. . J. Biol. Chem. Jul 2002, 277 (30): 27217–26. PMID 12000759. doi:10.1074/jbc.M202945200 .