CD132

CD132
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2B5I、2ERJ、3BPL、3QAZ、3QB7、4GS7
識別號
别名	IL2RG；, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
外部ID	OMIM：308380 MGI：96551 HomoloGene：172 GeneCards：IL2RG
相關疾病
	X性聯嚴重複合免疫缺乏症、combined immunodeficiency, X-linked[1]
為以下藥物的標靶
	denileukin diftitox[2]
基因位置（人类）
染色体	X染色體[3]
终止	71,112,108 bp[3]
基因位置（小鼠）
染色体	小鼠X染色体[4]
终止	100,311,861 bp[4]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• interleukin-7 receptor activity; • interleukin-2 receptor activity; • 血浆蛋白结合; • cytokine receptor activity; • interleukin-4 receptor activity; • interleukin-2 binding; • cytokine binding; • interleukin-15 receptor activity;
細胞組分	• integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • external side of plasma membrane; • 核内体; • 细胞质基质; • cell surface; • receptor complex;
生物學過程	• MAPK cascade; • 免疫反应; • viral process; • 訊息傳遞; • interleukin-2-mediated signaling pathway; • interleukin-4-mediated signaling pathway; • interleukin-7-mediated signaling pathway; • interleukin-15-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • regulation of molecular function; • cytokine-mediated signaling pathway; • interleukin-21-mediated signaling pathway; • positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
直系同源
	3561
	16186
	ENSG00000147168
	ENSMUSG00000031304
	P31785
	P34902
	NM_000206
	NM_013563; NM_001308535
	NP_000197
	NP_001295464; NP_038591
	維基數據

CD132，又称为共用γ链（Common gamma chain，缩写γ_c)，白介素2受体γ亚基（interleukin-2 receptor subunit gamma，缩写IL-2RG）是一种细胞因子受体亚基，存在于至少六种不同的白介素受体中：包括IL-2、IL-4[7]、IL-7[8]、IL-9、IL-15[9]和IL-21的受体。γ_c是I型细胞因子受体家族中的一种醣蛋白，表达于大部分的淋巴细胞群体，哺乳动物的此基因位于X染色体。

参考文献

.
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GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
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外部链接

醫學主題詞表（MeSH）：Interleukin+Receptor+Common+gamma+Subunit

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[1] .

[2] .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8266078-7] Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. . Science. December 1993, 262 (5141): 1880–3. PMID 8266078. doi:10.1126/science.8266078.

[pmid8266077-8] Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ. . Science. December 1993, 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077.

[pmid7641685-9] Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. . EMBO J. August 1995, 14 (15): 3654–63. PMC 394440 . PMID 7641685.