CD18

整联蛋白β-2（英語：，CD18）是一个由人类基因 ITGB2 编码的蛋白质，是整联蛋白的一种β亚基。

CD18
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1L3Y、​1YUK、​2JF1、​2P26、​2P28、​3K6S、​3K71、​3K72、​2V7D、​4NEH、​4NEN、​5E6X、​5E6V、​5E6S、​5E6R、​5E6W、​5ES4、​5E6U
識別號
别名	ITGB2；, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
外部ID	OMIM：600065 MGI：96611 HomoloGene：20092 GeneCards：ITGB2
相關疾病
leukocyte adhesion deficiency-1[1]
基因位置（人类） 染色体 21號染色體[2] 基因座 21q22.3 起始 44,885,953 bp[2] 终止 44,931,989 bp[2]
基因位置（小鼠） 染色体 小鼠10号染色体[3] 基因座 10 C1|10 39.72 cM 起始 77,366,086 bp[3] 终止 77,401,542 bp[3]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • 大分子复合物结合 • 金屬離子結合 • 血浆蛋白结合 • protein heterodimerization activity • ICAM-3 receptor activity • protein kinase binding • cell adhesion molecule binding • heat shock protein binding • amyloid-beta binding • complement component C3b binding • integrin binding • signaling receptor activity • cargo receptor activity 細胞組分 • integral component of membrane • 細胞外囊泡 • integrin alphaL-beta2 complex • 膜 • 细胞膜 • receptor complex • cell surface • integrin complex • 外排體 • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane • 粘着斑 • external side of plasma membrane • integrin alphaM-beta2 complex • plasma membrane raft • 脂筏模型 • cytoplasmic region • 大分子复合体 生物學過程 • leukocyte cell-cell adhesion • endodermal cell differentiation • toll-like receptor 4 signaling pathway • positive regulation of nitric oxide biosynthetic process • heterotypic cell-cell adhesion • cell-cell signaling • 老化 • receptor internalization • leukocyte migration involved in inflammatory response • natural killer cell activation • cellular response to low-density lipoprotein particle stimulus • extracellular matrix organization • receptor clustering • positive regulation of angiogenesis • neutrophil chemotaxis • 細胞粘附 • positive regulation of NF-kappaB transcription factor activity • regulation of cell shape • regulation of immune response • cellular extravasation • integrin-mediated signaling pathway • cell-matrix adhesion • inflammatory response • endothelial cell migration • leukocyte migration • regulation of peptidyl-tyrosine phosphorylation • 细胞凋亡 • 吞噬作用 • neutrophil degranulation • microglial cell activation • 受体介导的内吞作用 • phagocytosis, engulfment • 细胞迁移 • cytokine-mediated signaling pathway • positive regulation of superoxide anion generation • cell adhesion mediated by integrin • positive regulation of neutrophil degranulation • negative regulation of dopamine metabolic process • positive regulation of protein targeting to membrane • amyloid-beta clearance • cell-cell adhesion • cell-cell adhesion via plasma-membrane adhesion molecules • positive regulation of neuron death • positive regulation of microglial cell activation • neutrophil migration • positive regulation of prostaglandin-E synthase activity • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3689	16414
Ensembl	ENSG00000160255	ENSMUSG00000000290
UniProt	P05107	P11835
mRNA​序列	​NM_000211 ​NM_001127491 ​NM_001303238	NM_008404
蛋白序列	NP_000202 ​NP_001120963 ​NP_001290167	NP_032430
基因位置​（UCSC）	Chr 21: 44.89 – 44.93 Mb	Chr 10: 77.37 – 77.4 Mb
PubMed​查找	[4]	[5]
維基數據

能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：

• 淋巴球功能性抗原1，LFA-1 (搭配 CD11a)
• 巨噬细胞抗原的1 (搭配 CD11b)
• 整联蛋白αXβ2 (搭配 CD11c)
• 整联蛋白αDβ2 (搭配 CD11d)