CD29

CD29
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4WK4、3G9W、3T9K、3VI3、3VI4、4DX9、4WJK、4WK0、4WK2
識別號
别名	ITGB1；, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
外部ID	OMIM：135630 MGI：96610 HomoloGene：22999 GeneCards：ITGB1
基因位置（人类）
染色体	10號染色體[1]
终止	33,005,792 bp[1]
基因位置（小鼠）
染色体	小鼠8号染色体[2]
终止	129,459,681 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• virus receptor activity; • 金屬離子結合; • integrin binding; • 血浆蛋白结合; • laminin binding; • cell adhesion molecule binding; • collagen binding involved in cell-matrix adhesion; • coreceptor activity; • 蛋白酶結合; • fibronectin binding; • actin binding; • C-X3-C chemokine binding; • protein heterodimerization activity; • 大分子复合物结合; • cadherin binding; • signaling receptor activity;
細胞組分	• 細胞質; • 核内体; • 膜; • 黑色素体; • ruffle; • integrin alpha8-beta1 complex; • 突触; • ruffle membrane; • integrin complex; • 细胞质的核周区域; • cell projection; • 树突棘; • cell surface; • 分裂沟; • integrin alpha7-beta1 complex; • 外排體; • 板状伪足; • integral component of membrane; • recycling endosome; • integrin alpha1-beta1 complex; • 肌間盤; • 絲狀偽足; • 神经肌肉接点; • receptor complex; • 细胞膜; • integrin alpha11-beta1 complex; • myelin sheath abaxonal region; • synaptic membrane; • integrin alpha10-beta1 complex; • 细胞连接; • integrin alpha2-beta1 complex; • 肌膜; • external side of plasma membrane; • cytoplasmic vesicle; • integrin alpha3-beta1 complex; • 脂筏模型; • 粘着斑; • glial cell projection; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • integral component of synaptic membrane; • 大分子复合体;
生物學過程	• leukocyte cell-cell adhesion; • cell migration involved in sprouting angiogenesis; • stress fiber assembly; • 病毒进入; • B cell differentiation; • neuron projection development; • transforming growth factor beta receptor signaling pathway; • regulation of collagen catabolic process; • negative regulation of cell differentiation; • cardiac muscle cell differentiation; • cellular response to low-density lipoprotein particle stimulus; • in utero embryonic development; • cell-substrate adhesion; • positive regulation of GTPase activity; • regulation of immune response; • viral process; • dendrite morphogenesis; • cell fate specification; • G1期; • heterotypic cell-cell adhesion; • extracellular matrix organization; • cell-cell adhesion mediated by integrin; • cellular defense response; • 細胞粘附; • formation of radial glial scaffolds; • axon extension; • leukocyte tethering or rolling; • integrin-mediated signaling pathway; • cell-matrix adhesion; • sarcomere organization; • negative regulation of anoikis; • leukocyte migration; • homophilic cell adhesion via plasma membrane adhesion molecules; • visual learning; • calcium-independent cell-matrix adhesion; • cardiac muscle tissue development; • negative regulation of Rho protein signal transduction; • receptor internalization; • regulation of cell cycle; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • mesodermal cell differentiation; • 细胞迁移; • germ cell migration; • cell adhesion mediated by integrin; • basement membrane organization; • positive regulation of protein localization to plasma membrane; • G1/S transition of mitotic cell cycle; • 吞噬作用; • cytokine-mediated signaling pathway; • cell projection organization; • lamellipodium assembly; • positive regulation of angiogenesis; • modulation of chemical synaptic transmission; • positive regulation of protein kinase B signaling; • positive regulation of signaling receptor activity; • positive regulation of cell migration;
	Sources:Amigo / QuickGO
直系同源
	3688
	16412
	ENSG00000150093
	ENSMUSG00000025809
	P05556
	P09055
NM_002211; NM_033666; NM_033667; NM_033668; NM_033669;
	NM_133376
	NM_010578
	NP_002202; NP_391988; NP_596867
	NP_034708
	維基數據

整联蛋白β-1（英語：），也被称为 CD29 是一个由人类基因 ITGB1 编码的蛋白质[5]。CD29是整合素极晚期抗原受体的一个亚基。它与α-3亚基形成整合素α3β1，作为神经生长因子1和络丝蛋白的受体。在心肌和骨骼肌种，整联蛋白β-1会选择性表达为β-1D蛋白质异形体。

相互作用

CD29已经显示出与下列蛋白質交互作用：

ACTN1;[6][7]
CD46,[8]
CD9,[9][10]
FHL2,[11]
Filamin,[12][13]
FLNB,[12]
CD81,[10][14]
GNB2L1,[15][16]
ITGB1BP1,[17][18]
LGALS8,[19]
MAP4K4,[20]
NME1,[21]
PKC alpha,[15][22]
TLN1,[23][24]
TSPAN4,[25]
YWHAB[26]

参考文献

GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991. doi:10.1111/j.1469-1809.1989.tb01118.x.
Otey CA, Pavalko FM, Burridge K. . The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 . PMID 2116421. doi:10.1083/jcb.111.2.721.
Otey CA, Vasquez GB, Burridge K, Erickson BW. . The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808.
Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. . European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X.
Radford KJ, Thorne RF, Hersey P. . Biochemical and Biophysical Research Communications. May 1996, 222 (1): 13–8. PMID 8630057. doi:10.1006/bbrc.1996.0690.
Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. . Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7.
Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. . The Journal of Biological Chemistry. Oct 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.
van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. . The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 . PMID 11807098. doi:10.1083/jcb.200103037.
Loo DT, Kanner SB, Aruffo A. . The Journal of Biological Chemistry. Sep 1998, 273 (36): 23304–12. PMID 9722563. doi:10.1074/jbc.273.36.23304.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. . The Biochemical Journal. May 1999, 340 (Pt 1): 103–11. PMC 1220227 . PMID 10229664. doi:10.1042/0264-6021:3400103.
Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. . Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842.
Liliental J, Chang DD. . The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.
Chang DD, Wong C, Smith H, Liu J. . The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149.
Chang DD, Hoang BQ, Liu J, Springer TA. . The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200.
Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. . Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818.
Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E. . Current Biology. Apr 2002, 12 (8): 622–31. PMID 11967148. doi:10.1016/S0960-9822(02)00764-9.
Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. . The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200.
Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. . Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 . PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002.
Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. . Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126.
Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. . Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0.
Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. . The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181.
Han DC, Rodriguez LG, Guan JL. . Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068.

外部链接

醫學主題詞表（MeSH）：CD29+Antigen
Human ITGB1 genome location and ITGB1 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2524991-5] . Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991. doi:10.1111/j.1469-1809.1989.tb01118.x.

[6] Otey CA, Pavalko FM, Burridge K. . The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 . PMID 2116421. doi:10.1083/jcb.111.2.721.

[7] Otey CA, Vasquez GB, Burridge K, Erickson BW. . The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808.

[pmid10741407-8] Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. . European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X.

[pmid8630057-9] Radford KJ, Thorne RF, Hersey P. . Biochemical and Biophysical Research Communications. May 1996, 222 (1): 13–8. PMID 8630057. doi:10.1006/bbrc.1996.0690.

[pmid12175627-10] Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. . Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7.

[pmid10906324-11] Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. . The Journal of Biological Chemistry. Oct 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.

[pmid11807098-12] van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. . The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 . PMID 11807098. doi:10.1083/jcb.200103037.

[pmid9722563-13] Loo DT, Kanner SB, Aruffo A. . The Journal of Biological Chemistry. Sep 1998, 273 (36): 23304–12. PMID 9722563. doi:10.1074/jbc.273.36.23304.

[pmid10229664-14] Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. . The Biochemical Journal. May 1999, 340 (Pt 1): 103–11. PMC 1220227 . PMID 10229664. doi:10.1042/0264-6021:3400103.

[pmid12435334-15] Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. . Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842.

[pmid9442085-16] Liliental J, Chang DD. . The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.

[pmid9281591-17] Chang DD, Wong C, Smith H, Liu J. . The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149.

[pmid11741908-18] Chang DD, Hoang BQ, Liu J, Springer TA. . The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200.

[pmid10852818-19] Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. . Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818.

[pmid11967148-20] Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E. . Current Biology. Apr 2002, 12 (8): 622–31. PMID 11967148. doi:10.1016/S0960-9822(02)00764-9.

[pmid11919189-21] Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. . The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200.

[pmid12138200-22] Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. . Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 . PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002.

[23] Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. . Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126.

[24] Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. . Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0.

[pmid9360996-25] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. . The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181.

[pmid11313964-26] Han DC, Rodriguez LG, Guan JL. . Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068.