CD34

CD34
識別號
别名	CD34；, entrez:947, CD34 molecule
外部ID	OMIM：142230 MGI：88329 HomoloGene：1343 GeneCards：CD34
基因位置（人类）
染色体	1號染色體[1]
终止	207,911,402 bp[1]
基因位置（小鼠）
染色体	小鼠1号染色体[2]
终止	194,643,587 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 转录因子结合; • sulfate binding; • carbohydrate binding;
細胞組分	• 細胞質; • integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • 細胞外區域; • cell surface; • basal plasma membrane; • glomerular endothelium fenestra; • apical plasma membrane; • intercellular bridge; • 细胞质的核周区域; • 溶酶体; • external side of plasma membrane; • cell periphery;
生物學過程	• extracellular exosome assembly; • stem cell proliferation; • positive regulation of interleukin-10 production; • cell motility; • negative regulation of blood coagulation; • metanephric glomerular mesangial cell differentiation; • 旁分泌; • hematopoietic stem cell proliferation; • positive regulation of granulocyte colony-stimulating factor production; • negative regulation of gene expression; • positive regulation of angiogenesis; • 血压调节; • vascular wound healing; • positive regulation of gene expression; • glomerular filtration; • negative regulation of nitric oxide biosynthetic process; • 細胞粘附; • endothelial cell proliferation; • mesangial cell-matrix adhesion; • tissue homeostasis; • positive regulation of vasculogenesis; • endothelium development; • regulation of immune response; • negative regulation of cellular response to heat; • positive regulation of transforming growth factor beta production; • glomerular endothelium development; • 腫瘤壞死因子產生的負調控; • cell-matrix adhesion; • 細胞增殖; • positive regulation of odontogenesis; • negative regulation of cellular response to hypoxia; • leukocyte migration; • 訊息傳遞; • 分化轉移; • negative regulation of neuron death; • cell-cell adhesion; • 造血作用;
	Sources:Amigo / QuickGO
直系同源
	947
	12490
	ENSG00000174059
	ENSMUSG00000016494
	P28906
	Q64314
	NM_001025109; NM_001773
	NM_001111059; NM_133654
	NP_001020280; NP_001764
	NP_001104529; NP_598415
	維基數據

CD34（小鼠、大鼠的同源蛋白寫作Cd34），是一類分化簇（Cluster of differentiation, CD）分子，在人體內由CD34基因編碼，主要用來鑑定造血幹細胞（HSC）等成體幹細胞[5][6][7]。CD34化學本質爲糖蛋白，正常情況下位於細胞膜表面，功能包括參與細胞—細胞間黏附和細胞—細胞外基質（ECM）黏附。

功能

CD34最早於20世紀80年代由兩個課題組同時獨立發現，最初是用來鑑定一類造血幹細胞（CD34+陽性）。现在，是否表達CD34也是分離、鑑別造血幹細胞及其亚群（subpopulation）的一項重要指標[8][9][10][11][12][13]。CD34为单跨膜的黏液素（Mucin）類糖蛋白，通常分佈於細胞膜表面[14]。CD34功能複雜，至今CD34的功能仍然未完全闡明，已知的CD34分子功能主要是參與細胞黏附[15][16]。

分佈

CD34蛋白主要表達於造血幹細胞和造血祖細胞中，同時，血管內皮細胞、一部分間充質幹細胞（MSC）也表達CD34[17]。CD34在臍帶和骨髓中表達強度相對較高[18]。

參見

分化簇（CD）
CD44

參考

GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. （原始内容存档于2019-09-24）.
Simmons DL, Satterthwaite AB, Tenen DG, Seed B. . Journal of Immunology. Jan 1992, 148 (1): 267–71 [2018-02-14]. PMID 1370171. （原始内容存档于2008-06-06）.
Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG. . Genomics. Apr 1992, 12 (4): 788–94. PMID 1374051. doi:10.1016/0888-7543(92)90310-O.
Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. . Journal of Immunology. 1984, 133 (1): 157–65. PMID 6586833.
Tindle RW. Nichols R. Chan L. Campana D. Birnie GD. . Leukaemia Research. 1985, 9: 1–9. doi:10.1016/0145-2126(85)90016-5.
Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. . In 'Leucocyte typing 111: White cell differentiation antigens. Oxford University Press, 654-655. 1987.
Loken M. Shah V. Civin CI.. . In: McMichael, Leucocyte Typing III:White cell differentiation antigens.Oxford University Press 630-635. 1987.
Furness SG, McNagny K. . Immunologic Research. 2006, 34 (1): 13–32. PMID 16720896. doi:10.1385/IR:34:1:13.
Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, Thamaraikannan P, Abraham S. . Journal of Stem Cells and Regenerative Medicine. 2010 [2018-02-14]. （原始内容存档于2018-04-10）.
Nielsen JS, McNagny KM. . Journal of Cell Science. Nov 2008, 121 (Pt 22): 3683–92. PMID 18987355. doi:10.1242/jcs.037507.
Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM. . Immunity. Jan 2005, 22 (1): 43–57. PMID 15664158. doi:10.1016/j.immuni.2004.11.014.
Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E. . Developmental Cell. Oct 2009, 17 (4): 505–15. PMID 19853564. doi:10.1016/j.devcel.2009.08.011.
Ogawa M, Tajima F, Ito T, Sato T, Laver JH, Deguchi T. . Annals of the New York Academy of Sciences. Jun 2001, 938: 139–45. Bibcode:2001NYASA.938..139O. PMID 11458501. doi:10.1111/j.1749-6632.2001.tb03583.x.
Sidney LE, Branch MJ, Dunphy SE, Dua HS, Hopkinson A. . Stem Cells. Jun 2014, 32 (6): 1380–9. PMC 4260088 . PMID 24497003. doi:10.1002/stem.1661.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . （原始内容存档于2019-09-24）.

[pmid1370171-6] Simmons DL, Satterthwaite AB, Tenen DG, Seed B. . Journal of Immunology. Jan 1992, 148 (1): 267–71 [2018-02-14]. PMID 1370171. （原始内容存档于2008-06-06）.

[pmid1374051-7] Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG. . Genomics. Apr 1992, 12 (4): 788–94. PMID 1374051. doi:10.1016/0888-7543(92)90310-O.

[8] Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. . Journal of Immunology. 1984, 133 (1): 157–65. PMID 6586833.

[9] Tindle RW. Nichols R. Chan L. Campana D. Birnie GD. . Leukaemia Research. 1985, 9: 1–9. doi:10.1016/0145-2126(85)90016-5.

[10] Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. . In 'Leucocyte typing 111: White cell differentiation antigens. Oxford University Press, 654-655. 1987.

[11] Loken M. Shah V. Civin CI.. . In: McMichael, Leucocyte Typing III:White cell differentiation antigens.Oxford University Press 630-635. 1987.

[pmid16720896-12] Furness SG, McNagny K. . Immunologic Research. 2006, 34 (1): 13–32. PMID 16720896. doi:10.1385/IR:34:1:13.

[Srivastava_2010-13] Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, Thamaraikannan P, Abraham S. . Journal of Stem Cells and Regenerative Medicine. 2010 [2018-02-14]. （原始内容存档于2018-04-10）.

[pmid18987355-14] Nielsen JS, McNagny KM. . Journal of Cell Science. Nov 2008, 121 (Pt 22): 3683–92. PMID 18987355. doi:10.1242/jcs.037507.

[pmid15664158-15] Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM. . Immunity. Jan 2005, 22 (1): 43–57. PMID 15664158. doi:10.1016/j.immuni.2004.11.014.

[pmid19853564-16] Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E. . Developmental Cell. Oct 2009, 17 (4): 505–15. PMID 19853564. doi:10.1016/j.devcel.2009.08.011.

[17] Ogawa M, Tajima F, Ito T, Sato T, Laver JH, Deguchi T. . Annals of the New York Academy of Sciences. Jun 2001, 938: 139–45. Bibcode:2001NYASA.938..139O. PMID 11458501. doi:10.1111/j.1749-6632.2001.tb03583.x.

[18] Sidney LE, Branch MJ, Dunphy SE, Dua HS, Hopkinson A. . Stem Cells. Jun 2014, 32 (6): 1380–9. PMC 4260088 . PMID 24497003. doi:10.1002/stem.1661.